MAP2 (Microtubule Associated Protein 2) exists in two high molecular weight forms (MAP2a and MAP2b) and a low molecular weight form. The expression of MAP2 is developmentally regulated and its multiple forms arise by alternative splicing of a single gene. MAP2 is involved in microtubule assembly, which is an essential step in neurogenesis. The products of similar genes in rat and mouse are neuron-specific cytoskeletal proteins that are enriched in dendrites, implicating a role in determining and stabilizing dendritic shape during neuron development. MAP2 is useful in studies of neuron structure in normal and malignant brain tissue as well as in degenerative diseases such as Alzheimer's Disease (AD).
AC091465.1; DKFZp686I2148; MAP-2; map-2a; map2ab; microtubule associated protein 2C; Microtubule-associated protein 2; OTTHUMP00000163916; OTTHUMP00000208143
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