|Tested species reactivity||Human|
|Host / Isotype||Rabbit / IgG|
|Immunogen||A 13 amino acid synthetic peptide near the amino terminus of human TAB3|
|Purification||Antigen affinity chromatography|
|Contains||0.02% sodium azide|
|Storage Conditions||Maintain refrigerated at 2-8°C for up to 3 months. For long term storage store at -20°C|
|Tested Applications||Dilution *|
|Immunohistochemistry (IHC)||5 ug/mL|
A suggested positive control is human kidney tissue.
PA5-34366 can be used with blocking peptide PEP-1409.
TAB3 functions in the NF-kappaB signal transduction pathway. It and the similar and functionally redundant protein TAB2, form a ternary complex with the protein kinase TAK1 and either TRAF2 or TRAF6 in response to stimulation with the pro-inflammatory cytokines TNF or IL-1. Subsequent TAK1 kinase activity triggers a signaling cascade leading to activation of the NF-kappaB transcription factor. Recent experiments have shown that TAB2 and the related protein TAB3 constitutitvely interact with the autophagy mediator Beclin-1; upon induction of autophagy, these proteins dissociate from Beclin-1 and bind TAK1. Overexpression of TAB2 and TAB3 inhibit autophagy, while their depletion triggers it, suggesting that TAB2 and TAB3 act as a control point for autophagy.
MAP3K7-interacting protein 3; MAP3K7IP3; mitogen-activated protein kinase kinase kinase 7 interacting protein 3; NF-kappa-B-activating protein 1; NFkB activating protein 1; TAB-3; TAB3; TAK1-binding protein 3; TGF-beta-activated kinase 1-binding protein 3
MAP3K7IP3; NAP1; TAB3