This gene is a member of a conserved family of genes that share a common DNA-binding domain, the T-box. T-box genes encode transcription factors involved in the regulation of developmental processes. A similar protein has been disrupted in mice and shown to be critical for early cortical development, and causes loss of projection neurons in the olfactory bulbs and olfactory cortex. The C-terminal region this similar protein was found to be necessary and sufficient for association with the guanylate kinase domain of calcium/calmodulin-dependent serine protein kinase.
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Protein Aliases: T-box brain gene 1; T-box brain protein 1; T-box, brain, 1; T-box, brain, 1-like; T-brain-1; TBR-1; TES-56
Gene Aliases: TBR-1; TBR1; TES-56