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|Tested species reactivity||Human, Mouse, Rat|
|Host / Isotype||Rabbit / IgG|
|Immunogen||A 19 amino acid peptide from near the carboxy terminus of human TMP21.|
|Purification||Antigen affinity chromatography|
|Contains||0.02% sodium azide|
|Storage Conditions||Maintain refrigerated at 2-8°C for up to 3 months. For long term storage store at -20°C|
|Tested Applications||Dilution *|
|Immunocytochemistry (ICC)||20 ug/ml|
|Immunofluorescence (IF)||20 ug/ml|
|Immunohistochemistry (IHC)||2.5 µg/ml|
|Western Blot (WB)||0.5-2 µg/ml|
* Suggested working dilutions are given as a guide only. It is recommended that the user titrate the product for use in their own experiment using appropriate negative and positive controls.
A suggested positive control is Raji cell lysate.
PA5-20315 can be used with blocking peptide PEP-0435.
TMP21 is a ubiquitously expressed protein that is involved in vesicular targeting and protein transport. More recent experiments have shown that it is also a component in the presenilin complex and modulates the -gamma-secretase but not the epsilon-secretase cleavage activity of the amyloid precursor protein. The presenilin complex is composed of the proteins APH1, nicastrin, and PEN2 in addition to presenilin-1. Together, these proteins cleave the amyloid precursor protein at what is known as the -gamma- and epsilon-sites and can lead to the accumulation of the Abeta cleavage product that is associated with Alzheimer"e;s disease. Co-immunoprecipitation experiments using antibodies against these proteins also yielded TMP21 indicating that TMP21 may play a role in the regulation of this complex. Suppression of TMP21 expression by siRNA in transfected cells caused increased -gamma-secretase activity but not epsilon-secretase activity, and increased Abeta production, demonstrating that TMP21 can modulate -gamma-secretase activity.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
21 kDa transmembrane trafficking protein; 21 kDa transmembrane-trafficking protein; integral membrane protein Tmp21-I (p23); p24 family protein delta-1; P24(DELTA), S31I125, S31III125, TMP21, Tmp-21-I, p23; p24delta; p24delta1; testicular tissue protein Li 206; transmembrane emp24 domain-containing protein 10; transmembrane emp24-like trafficking protein 10; transmembrane protein Tmp21; transmembrane trafficking protein; transmembrane trafficking protein 21
1110014C03Rik; p23; P24(DELTA); p24d1; p24delta1; S31I125; S31III125; TMED10; Tmp-21-I; TMP21