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Proteintech
TPMT Polyclonal Antibody
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Product Details
10682-1-AP
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
TPMT Fusion Protein Ag1074 (1-245 aa encoded by BC005339)
Conjugate
Form
Liquid
Concentration
0.15 mg/mL
Amount
22.5 µg
Purification
Antigen affinity chromatography
Storage buffer
PBS, pH 7.3, with 50% glycerol
Contains
0.02% sodium azide
Storage conditions
-20°C
Shipping conditions
Wet ice (domestic); Dry ice (international)
Product Specific Information
This antibody specifically recognizes the 34 kDa protein.
Immunogen sequence: MDGTRTSLD IEEYSDTEVQ KNQVLTLEEW QDKWVNGKTA FHQEQGHQLL KKHLDTFLKG KSGLRVFFPL CGKAVEMKWF ADRGHSVVGV EISELGIQEF FTEQNLSYSE EPITEIPGTK VFKSSSGNIS LYCCSIFDLP RTNIGKFDMI WDRGALVAIN PGDRKCYADT MFSLLGKKFQ YLLCVLSYDP TKHPGPPFYV PHAEIERLFG KICNIRRLEK VDAFEERHKS WGIDCLFEKL YLLTEK (1-245 aa encoded by B C005339)
Target Information
Catalyzes the S-methylation of thiopurine drugs such as 6-mercaptopurine. Defects in TPMT are the cause of thiopurine S-methyltransferase deficiency (TPMT deficiency). TPMT is an enzyme involved in the normal metabolic inactivation of thiopurine drugs. These drugs are generally used as immunosupressants or cytotoxic drugs and are prescribed for a variety of clinical conditions including leukemia, autoimmune disease and organ transplantation. Patients with intermediate or no TPMT activity are at risk of toxicity after receiving standard doses of thiopurine drugs and it is shown that inter-individual differences in response to these drugs are largely determined by genetic variation at the TPMT locus.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Bioinformatics
Protein Aliases: HGNC:12014; S-adenosyl-L-methionine:thiopurine S-methyltransferase; Thiopurine methyltransferase; Thiopurine S-methyltransferase
Gene Aliases: AW106912; TPMT; TPMTD
UniProt ID: (Human) P51580, (Rat) Q9Z0T0, (Mouse) O55060
Entrez Gene ID: (Human) 7172, (Rat) 690050, (Mouse) 22017
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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