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Proteintech

TRBP Polyclonal Antibody, CoraLite® Plus 488

View all (18) TRBP antibodies

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Product Details

CL488-15753

Applications
Tested Dilution
Publications

Immunocytochemistry (ICC/IF)

1:50-1:500
-

Flow Cytometry (Flow)

0.80 µg/10^6 cells in a 100 µL suspension
-
Product Specifications

Species Reactivity

Human, Mouse, Rat

Host/Isotype

Rabbit / IgG

Class

Polyclonal

Type

Antibody

Immunogen

TRBP fusion protein Ag8255

Conjugate

CoraLite® Plus 488 CoraLite® Plus 488 CoraLite® Plus 488

Excitation/Emission Max

493/522 nm

Form

Liquid

Concentration

1 mg/mL

Amount

100 µg

Purification

Antigen affinity chromatography

Storage buffer

PBS, pH 7.3, with 50% glycerol, 0.5% BSA

Contains

0.05% ProClin 300

Storage conditions

-20°C, store in dark

Shipping conditions

Wet ice

Product Specific Information

Immunogen sequence: MSEEEQGSG TTTGCGLPSI EQMLAANPGK TPISLLQEYG TRIGKTPVYD LLKAEGQAHQ PNFTFRVTVG DTSCTGQGPS KKAAKHKAAE VALKHLKGGS MLEPALEDSS SFSPLDSSLP EDIPVFTAAA AATPVPSVVL TRSPPMELQP PVSPQQSECN PVGALQELVV QKGWRLPEYT VTQESGPAHR KEFTMTCRVE RFIEIGSGTS KKLAKRNAAA KMLLRVHTVP LDARDGNEVE PDDDHFSIGV GSRLDGLRNR GPGCTWDSLR NSVGEKILSL RSCSLGSLGA LGPACCRVLS ELSEEQAFHV SYLDIEELSL SGLCQCLVEL STQPATVCHG SATTREAARG EAARRALQYL KIMAGSK

Target Information

TRBP belongs to the family of dsRNA-binding proteins. It consists of highly conserved 2 dsRNA-binding domains and C-terminal basic region. It is a unique cellular protein capable of binding to HIV-TAR RNA and stimulates expression of HIV-1 long terminal repeats. It also inhibits the host antiviral and anti-proliferative mechanisms by directly binding to IFN-regulated dsRNA-dependent protein kinase (PKR). TRBP associates with Ago2 protein and forms an integral component of Dicer-containing complex. It has a role in micro RNA processing and in RISC assembly. Other functions of TRBP include promoting cellular growth and tumorigenesis.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

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Bioinformatics

Protein Aliases: PRM-1 RNA-binding protein; Protamine-1 RNA-binding protein; RISC-loading complex subunit TARBP2; RISC-loading complex subunit TARBP2 {ECO:0000255|HAMAP-Rule:MF_03034}; TAR (HIV) RNA binding protein 2; TAR (HIV) RNA-binding protein 2; TAR (HIV) RNA-binding protein TRBP1; TAR (HIV-1) RNA binding protein 2; TAR RNA binding protein 2; TAR RNA-binding protein 2; TARBP2, RISC loading complex RNA binding subunit; trans-activation responsive RNA-binding protein; Trans-activation-responsive RNA-binding protein; unnamed protein product

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Gene Aliases: LOQS; Prbp; TARBP2; TRBP; TRBP1; TRBP2

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UniProt ID: (Human) Q15633, (Mouse) P97473, (Rat) Q3SWU0

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Entrez Gene ID: (Human) 6895, (Mouse) 21357, (Rat) 363006

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Function(s)
RNA binding double-stranded RNA binding protein binding enzyme binding siRNA binding miRNA binding pre-mRNA binding identical protein binding protein homodimerization activity pre-miRNA binding protein sequestering activity molecular_function
Process(es)
regulation of translation spermatid development single fertilization production of siRNA involved in RNA interference targeting of mRNA for destruction involved in RNA interference gene silencing by RNA pre-miRNA processing siRNA loading onto RISC involved in RNA interference production of miRNAs involved in gene silencing by miRNA multicellular organism growth miRNA loading onto RISC involved in gene silencing by miRNA positive regulation of viral genome replication positive regulation of translation regulation of viral transcription negative regulation of defense response to virus by host cytoplasmic pattern recognition receptor signaling pathway negative regulation of protein kinase activity posttranscriptional regulation of gene expression negative regulation of viral-induced cytoplasmic pattern recognition receptor signaling pathway skeletal muscle tissue regeneration positive regulation of muscle cell differentiation regulation of protein metabolic process neural precursor cell proliferation protein K63-linked ubiquitination regulation of production of small RNA involved in gene silencing by RNA regulation of production of siRNA involved in chromatin silencing by small RNA small RNA loading onto RISC global gene silencing by mRNA cleavage regulation of production of miRNAs involved in gene silencing by miRNA biological_process
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If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*

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