Thought to form a receptor-activated non-selective calcium permeant cation channel. Probably is operated by a phosphatidylinositol second messenger system activated by receptor tyrosine kinases or G-protein coupled receptors. Seems to be also activated by intracellular calcium store depletion. Interacts with ITPR3. Appears to be ubiquitous.
Protein Aliases: 3010009O07Rik; AI115608; capacitative calcium channel protein Trp1; membe; mTrp2; Short transient receptor potential channel 1; smTRPC2; transient receptor potential canonical 1; transient receptor potential cation channel, subfamily C, member 1; Transient receptor protein 1; TRP-1; TRP-1 protein; Trp-related protein 1; trp2; TrpC1; TRPC2a; TRPC2b; Trrp2
Gene Aliases: HTRP-1; Mtrp1; TRP1; TRPC1; Trrp1