Immunogen sequence: HEDKEWKFAR AKLWLSYFDD KCTLPPPFNI IPSPKTICYM ISSLSKWICS HTSKGKVKRQ NSLKEWRNLK QKRDENYQKV MCCLVHRYLT SMRQKMQSTD QATVENLNEL RQDLSKFRNE IRDLLGFRTS KYA
Highest antigen sequence identity to the following orthologs: Mouse - 100%, Rat - 98%.
Thought to form a receptor-activated non-selective calcium permeant cation channel. Probably is operated by a phosphatidylinositol second messenger system activated by receptor tyrosine kinases or G-protein coupled receptors. Seems to be also activated by intracellular calcium store depletion. Interacts with ITPR3. Appears to be ubiquitous.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Protein Aliases: capacitative calcium channel protein Trp1; membe; Short transient receptor potential channel 1; subfamily C; transient receptor potential canonical 1; transient receptor potential cation channel, subfamily C, member 1; Transient receptor protein 1; TRP-1; TRP-1 protein; Trp1; TrpC1; Trpc1 transient receptor potential cation channel; Trrp1
Gene Aliases: HTRP-1; TRP1; TRPC1
UniProt ID: (Human) P48995
Entrez Gene ID: (Human) 7220