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Immunogen sequence: MEEGSSSPV SPVDSLGTSE EELERQPKRF GRKRRYSKKS SEDGSPTPGK RGKKGSPSAQ SFEELQSQRI LANVRERQRT QSLNEAFAAL RKIIPTLPSD KLSKIQTLKL AARYIDFLYQ VLQSDEMDNK MTSCSYVAHE RLSYAFSVWR MEGAWSMSAS H (1-160 aa encoded by BC033168)
Binds to the E-box consensus sequence 5'-CANNTG-3' as a heterodimer and inhibits transcriptional activation by MYOD1, MYOG, MEF2A and MEF2C. Also represses expression of proinflammatory cytokines such as TNFA and IL1B. Involved in postnatal glycogen storage and energy metabolism. Inhibits the premature or ectopic differentiation of preosteoblast cells during osteogenesis, possibly by changing the internal signal transduction response of osteoblasts to external growth factors.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Protein Aliases: bHLHa39; Class A basic helix-loop-helix protein 39; dermis expressed 1; Dermis-expressed protein 1; Dermo-1; dermo-1 protein; twist basic helix-loop-helix transcription factor 2; twist homolog 2; twist-related bHLH protein Dermo1; Twist-related protein 2
Gene Aliases: AMS; BBRSAY; BHLHA39; DERMO1; FFDD3; SETLSS; TWIST2
Molecular Function: basic helix-loop-helix transcription factor