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Bioss
UHRF1/2 Polyclonal Antibody
Product Details
BS-6427R
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
KLH conjugated synthetic peptide derived from human UHRF1.
Conjugate
Form
Liquid
Concentration
1 mg/mL
Purification
Protein A
Storage buffer
0.01M TBS, pH 7.4, with 1% BSA, 50% glycerol
Contains
0.02% ProClin 300
Storage conditions
-20°C
Shipping conditions
Ambient (domestic); Wet ice (international)
Target Information
Putative E3 ubiquitin-protein ligase. May participate in methylation-dependent transcriptional regulation. Binds to inverted 5'-CCAAT-3' box 2 in the TOP2A promoter, and activates TOP2A expression. Important for G1/S transition. May be involved in DNA repair and chromosomal stability. Tissue specificity: Expressed in thymus, bone marrow, testis, lung and heart. Overexpressed in breast cancer. UHRF2 is an E3 ubiquitin-protein ligase that is an intermolecular hub protein in the cell cycle network. Through cooperative DNA and histone binding, may contribute to a tighter epigenetic control of gene expression in differentiated cells. Ubiquitinates cyclins, CCND1 and CCNE1, in an apparently phosphorylation-independent manner and induces G1 arrest. Also ubiquitinates PCNP leading to its degradation by the proteasome. E3 SUMO-, but not ubiquitin-, protein ligase for ZNF131.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: E3 ubiquitin-protein ligase UHRF1; E3 ubiquitin-protein ligase UHRF2; hUHRF1; HuNp95; Inverted CCAAT box-binding protein of 90 kDa; liver regeneration-related protein LRRG126; mUhrf1; NIRF; Np95-like RING finger protein; Np95/ICBP90-like RING finger protein; nuclear phosphoprotein 95; Nuclear protein 95; Nuclear protein 97; Nuclear zinc finger protein Np95; Nuclear zinc finger protein Np97; RING finger protein 106; RING finger protein 107; RING-type E3 ubiquitin transferase UHRF1; RING-type E3 ubiquitin transferase UHRF2; Transcription factor ICBP90; Ubiquitin-like PHD and RING finger domain-containing protein 1; Ubiquitin-like PHD and RING finger domain-containing protein 2; ubiquitin-like with PHD and ring finger domains 1; ubiquitin-like with PHD and ring finger domains 2, E3 ubiquitin protein ligase; ubiquitin-like, containing PHD and RING finger domains 2; ubiquitin-like, containing PHD and RING finger domains, 1; ubiquitin-like, containing PHD and RING finger domains, 2; Ubiquitin-like-containing PHD and RING finger domains protein 1; Ubiquitin-like-containing PHD and RING finger domains protein 2
Gene Aliases: 2310065A22Rik; Ac2-121; AI426270; AL022808; AW214556; D130071B19Rik; hNP95; hUHRF1; huNp95; ICBP90; NIRF; NP95; RNF106; RNF107; TDRD22; TDRD23; UHRF1; UHRF2; URF2
UniProt ID: (Human) Q96T88, (Human) Q96PU4, (Mouse) Q8VDF2, (Mouse) Q7TMI3
Entrez Gene ID: (Human) 29128, (Human) 115426, (Mouse) 18140, (Rat) 316129, (Rat) 309331, (Mouse) 109113
core promoter proximal region sequence-specific DNA binding
transcription factor activity, sequence-specific DNA binding
ubiquitin-protein transferase activity
protein binding
zinc ion binding
methyl-CpG binding
ligase activity
nucleosomal histone binding
methylated histone binding
histone binding
identical protein binding
hemi-methylated DNA-binding
ubiquitin protein ligase activity
DNA binding
UDP-N-acetylmuramoylalanyl-D-glutamyl-2,6-diaminopimelate-D-alanyl-D-alanine ligase activity
ribosomal S6-glutamic acid ligase activity
coenzyme F420-0 gamma-glutamyl ligase activity
coenzyme F420-2 alpha-glutamyl ligase activity
metal ion binding
protein-glycine ligase activity
protein-glycine ligase activity, initiating
protein-glycine ligase activity, elongating
tubulin-glycine ligase activity
protein-glutamic acid ligase activity
tubulin-glutamic acid ligase activity
molecular_function
ubiquitin-protein ligase
negative regulation of transcription from RNA polymerase II promoter
DNA repair
transcription, DNA-templated
cell cycle
cell proliferation
maintenance of DNA methylation
histone monoubiquitination
histone ubiquitination
positive regulation of cellular protein metabolic process
protein ubiquitination involved in ubiquitin-dependent protein catabolic process
positive regulation of transcription from RNA polymerase II promoter
protein autoubiquitination
regulation of methylation-dependent chromatin silencing
positive regulation of DNA topoisomerase (ATP-hydrolyzing) activity
protein ubiquitination
cell differentiation
regulation of cell cycle
positive regulation of cell cycle arrest
regulation of transcription, DNA-templated
cellular response to DNA damage stimulus
chromatin modification
response to peptide hormone
ubiquitin-dependent protein catabolic process
biological_process
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