UHRF1/UHRF2 Antibodies

Target Information

Putative E3 ubiquitin-protein ligase. May participate in methylation-dependent transcriptional regulation. Binds to inverted 5'-CCAAT-3' box 2 in the TOP2A promoter, and activates TOP2A expression. Important for G1/S transition. May be involved in DNA repair and chromosomal stability. Tissue specificity: Expressed in thymus, bone marrow, testis, lung and heart. Overexpressed in breast cancer. UHRF2 is an E3 ubiquitin-protein ligase that is an intermolecular hub protein in the cell cycle network. Through cooperative DNA and histone binding, may contribute to a tighter epigenetic control of gene expression in differentiated cells. Ubiquitinates cyclins, CCND1 and CCNE1, in an apparently phosphorylation-independent manner and induces G1 arrest. Also ubiquitinates PCNP leading to its degradation by the proteasome. E3 SUMO-, but not ubiquitin-, protein ligase for ZNF131.

Synonyms

2310065A22Rik; Ac2-121; AI426270; AL022808; AW214556; D130071B19Rik; E3 ubiquitin-protein ligase UHRF1; E3 ubiquitin-protein ligase UHRF2; hNP95; hUHRF1; huNp95; ICBP90; inverted CCAAT box-binding protein of 90 kDa; Liver regeneration-related protein LRRG126; mUhrf1; Nirf; NP95; Np95/ICBP90-like RING finger protein; Np95-like ring finger protein; nuclear phosphoprotein 95; nuclear protein 95; Nuclear protein 97; nuclear zinc finger protein Np95; Nuclear zinc finger protein Np97; RING finger protein 106; RING finger protein 107; RING-type E3 ubiquitin transferase UHRF1; RING-type E3 ubiquitin transferase UHRF2; RNF106; RNF107; TDRD22; TDRD23; Transcription factor ICBP90; ubiquitin like with PHD and ring finger domains 1; ubiquitin like with PHD and ring finger domains 2; ubiquitin-like PHD and RING finger domain-containing protein 1; Ubiquitin-like PHD and RING finger domain-containing protein 2; ubiquitin-like with PHD and ring finger domains 1; ubiquitin-like with PHD and ring finger domains 2, E3 ubiquitin protein ligase; ubiquitin-like, containing PHD and RING finger domains 2; ubiquitin-like, containing PHD and RING finger domains, 1; ubiquitin-like, containing PHD and RING finger domains, 2; ubiquitin-like-containing PHD and RING finger domains protein 1; Ubiquitin-like-containing PHD and RING finger domains protein 2; UHRF1; UHRF2; URF2