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Invitrogen
ZIP12 Polyclonal Antibody
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FIGURE: 1 / 1
ZIP12 Antibody (PA5-90883) in WB
Western blot analysis of ZIP12 in extracts of various cell lines. Samples were incubated with ZIP12 Polyclonal antibody (Product # PA5-90883) using a dilution of 1:1,000, followed by HRP Goat Anti-Rabbit IgG (H+L) at a dilution of 1:10,000. Lysates/proteins: 25 µg per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit. Exposure time: 1s.
Product Details
PA5-90883
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
A synthetic peptide corresponding to a sequence within amino acids 1-100 of human SLC39A12 (NP_0011386671)
Conjugate
Form
Liquid
Concentration
1.07 mg/mL
Amount
107 µg
Purification
Affinity Chromatography
Storage buffer
PBS, pH 7.3, with 50% glycerol
Contains
0.01% thimerosal
Storage conditions
-20°C, Avoid Freeze/Thaw Cycles
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Product Specific Information
Immunogen sequence: MCFRTKLSVS WVPLFLLLSR VFSTETDKPS AQDSRSRGSS GQPADLLQVL SAGDHPPHNH SRSLIKTLLE KTGCPRRRNG MQGDCNLCFE PDALLLIAGG; Positive Samples: 293T, mouse brain, mouse eye, mouse lung, rat brain
Target Information
The zinc transporter ZIP12, also known as SLC39A12, is a member of a family of divalent ion transporters. Zinc is an essential ion for cells and plays significant roles in the growth, development, and differentiation. The zinc transporter family is divided into four subfamilies (I, II, LIV-1 and gufA). ZIP12 is a multipass membrane protein that belongs to the ZIP transporter subfamily LIV-1. Increased levels of ZIP12 have been observed during acute inflammation in the airway and asthma, suggesting that it may be promote increased zinc uptake, as this can reduce inflammation. The zinc content in brains in individuals with schizophrenia is lower than in individuals with other cerebral diseases, and mutations in ZIP12 have been observed in a small group of schizophrenic patients, suggesting that ZIP12 may play a role in this disease.
⚠WARNING: This product can expose you to chemicals including mercury, which is known to the State of California to cause birth defects or other reproductive harm. For more information go to www.P65Warnings.ca.gov.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: LIV-1 subfamily of ZIP zinc transporter 8; LZT-Hs8; solute carrier family 39 (metal ion transporter), member 12; solute carrier family 39 (zinc transporter), member 12; Solute carrier family 39 member 12; unnamed protein product; zinc transporter 12; Zinc transporter ZIP12; ZIP-12; Zrt- and Irt-like protein 12; ZRT/IRT-like protein 12
Gene Aliases: AW046938; bA570F3.1; Gm731; LZT-Hs8; SLC39A12; ZIP-12; ZIP12
UniProt ID: (Human) Q504Y0, (Mouse) Q5FWH7
Entrez Gene ID: (Human) 221074, (Mouse) 277468, (Rat) 291328
neural tube formation
ion transport
zinc II ion transport
signal transduction
regulation of neuron projection development
bicarbonate transport
metal ion transport
cellular cation homeostasis
regulation of microtubule polymerization
transmembrane transport
zinc II ion transmembrane import
neuron projection extension
divalent inorganic cation transport
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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