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Invitrogen
p53AIP1 Polyclonal Antibody
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Product Details
PA1-29529
Applications
Tested Dilution
Publications
Product Specifications
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Synthetic peptide corresponding to amino acids GSAFELSYDQKKAPLR of human p53AIP1
Conjugate
Form
Liquid
Concentration
0.2 mg/mL
Amount
50 µg
Storage conditions
4°C, do not freeze
Shipping conditions
Wet ice
Product Specific Information
PA1-29529 detects p53 AIP1 from human samples.
PA1-29529 has been successfully used in Western blot applications.
The PA1-29529 immunogen is: Synthetic peptide - amino acids GSAFELSYDQKKAPLR of human p53AIP1
Target Information
The novel protein p53AIP, p53-regulated apoptosis-inducing protein 1, has been identified from the direct cloning of p53 binding sequences from human genomic DNA. The expression of p53AIP1 in mitochondria is induced by wild-type p53, which leads to apoptotic cell death through dissipation of mitochondrial Dym. Severe DNA damage causes the phosphorylation of p53 at Ser-46, p53AIP1 expression, and apoptotic cell death. DNA damage-inducible apoptotic cell death was enhanced through transcriptional activation of p53AIP1. P53R2 is directly regulated by p53 for supplying nucleotides to repair damaged DNA, thus plays a pivotal role in cell survival by repairing damaged DNA in the nucleus and that dysfunction of this pathway might result in activation of p53 dependent apoptosis to eliminate dangerous cells. In the opposite, p53AIP1 is likely to play an important role in mediating p53-dependent apoptosis, and phosphorylation of Ser46 regulates the transcriptional activation of this apoptosis inducing gene.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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