High-performance biopharmaceutical characterization for everyone!
I’ve just recently celebrated five years in my current role here at Thermo Fisher Scientific. Wow, where did those years go? I love what I do, but it does mean that it’s been five whole years since I had my very own mass spectrometer to look after. Although mass spectrometry is still very much part of my life, I do miss being greeted each morning with the green lights of my Orbitrap.
In all honesty, my fifteen or so years working with MS, haven’t all been plain sailing! There’s been late nights and lost weekends spent in the lab, trying to get things to work and more than a couple of naughty words muttered under my breath. One thing is for sure as the years pass, MS becomes more and more user-friendly. This seems especially apparent in the last few years.
Take the Thermo Scientific Orbitrap Exploris 240 mass spectrometer, a fourth-generation hybrid quadrupole-Orbitrap mass spectrometer benefiting from over twenty years of engineering experience. The platform provides simplification of operational procedures and high-performance biopharmaceutical characterization accessible to everyone.
With superb spectral clarity, the Orbitrap Exploris 240 delivers the high-confidence characterization required to reliably quantitate and identify biotherapeutics in both research and routine laboratory environments. From intact mass analysis under denaturing and native conditions to subunit analysis, middle- and top-down analysis, and peptide or disulfide bond mapping; it maximizes productivity through improved flexibility, speed and dependability.
Discover how the Orbitrap Exploris 240 is an ideal instrument platform for performing MS analysis of intact biopharmaceuticals under native conditions. Utilizing charge variant analysis, the platform enables in-depth characterization and confident identification of mAb microheterogeneity due to excellent sensitivity and spectral quality.
See how these latest advances in high-resolution accurate-mass (HRAM) MS can be deployed to pinpoint site-specific identification of oxidation hotspots in therapeutic proteins and detect with confidence low-level methionine oxidation through diagnostic MS/MS fragmentation at the peptide level.
Find out how the system delivers operational simplicity and walk-up performance without the requirement for complex setup and tuning procedures.