Efficient Strategies for High-Density Cell Culture Harvesting

Optimize your high-density cell culture workflow

In the ever-evolving field of bioprocessing, efficiency, and optimization are key to maintaining a competitive edge and reducing operational costs. This application note explores how the Thermo Scientific DynaSpin Single-Use Centrifuge can be used as an advanced tool to help determine strategies for harvesting high-density cell cultures. Explore this comprehensive analysis of the benefits offered by the DynaSpin Single-Use Centrifuge, backed by practical data and real-world examples.

Three main areas of improvement

This application note explores how the DynaSpin Single-Use Centrifuge can advance harvesting high-density cell cultures by focusing on three main areas of improvement significant reduction in filter area, operational efficiency, and space and resource optimization.

1. Significant reduction in filter area

Traditional depth filtration methods require substantial filter surface area, which can be a bottleneck in harvesting high-density cell cultures. The DynaSpin Single-Use Centrifuge addresses this by reducing the filter surface area by up to 83% for fed-batch harvests. This significant reduction not only helps to lower costs but also enables a simplified filtration process.

2. Operational efficiency

Time is a critical factor in bioprocessing, and the DynaSpin Single-Use Centrifuge excels in this aspect. The application note reveals that the centrifuge can cut harvest time from 26 hours to as little as 5.5 hours. Additionally, it reduces buffer usage from 13,100 liters to 1,250 liters. These improvements translate to substantial time and resource savings, enhancing overall productivity.

3. Space and resource optimization

Space constraints are a common challenge in bioprocessing facilities. The DynaSpin Single-Use Centrifuge is designed to minimize the number of depth filters required from 75 to just 10, significantly reducing its overall footprint. This optimization allows for better utilization of available space and further contributes to cost savings.

Conclusions

The Thermo Scientific DynaSpin Single-Use Centrifuge can help optimize bioprocessing workflows by reducing filter area, cutting down on harvest time, and optimizing space and resources—making it an excellent asset for any bioprocessing facility.
For bioprocessing professionals looking to enhance their workflows, the DynaSpin Single-Use Centrifuge presents a compelling solution. This case study highlights the tangible benefits of this innovative technology, making a strong case for its adoption in modern bioprocessing facilities.

Read the full application note here

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