At GSK, charged aerosol detection is an established detector for impurities analysis. There is a limitation to the charged aerosol detector running gradient analysis due to the change in solvent composition creating response differences of the analytes over the course of a run which leads to the need to externally standardize the determination of the analytes. At GSK, a custom-built system to compensate for solvent composition changes during gradient.
Thermo Fisher Scientific offers a complete solution that is capable of simultaneously delivering a chromatographic gradient and an inverse gradient.
The development of method and comparison of data generated across the custom-built and ready-made systems was carried out at GSK and details of the work will be presented.
Attend this webinar to learn
- Learn how the charged aerosol detector helps in the analysis of unknown impurities even with gradient separation
- Observe the successful method transfer and comparisons between different HPLC-CAD setups with inverse gradient
- Recognize the productivity gain with the Thermo Scientific Vanquish Duo UHPLC System for Inverse Gradient LC
Who should attend
People interested in the analysis of unknown impurities, and anyone being faced with the challenge of how to separate, detect and quantify impurities.