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A complete toolset for your gene modified T cell manufacturing workflow
A streamlined workflow that enables precise genetic modifications in T cells, helping pave the way for targeted cancer treatments and advancements in cellular. Navigate to each stage of the workflow below.
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1. Cell isolation and activation
Isolation and activation of T cells:
- Gibco CTS Detachable Dynabeads CD4
- Gibco CTS Detachable Dynabeads CD8
- Gibco CTS Detachable Dynabeads CD/3CD28
- Gibco CTS Detachable Dynabeads Release Buffer
- Invitrogen Dynabeads magnetic beads for cell isolation, expension and activation
- Thermo Scientific KingFisher Apex Purification System
- Gibco CTS Dynabeads CD3/CD28
- Gibco CTS Dynabeads Treg Xpander
- Gibco CTS DynaCellect Magnetic Separation System
- Gibco CTS DynaMag Magnet
- Thermo Scientific Herasafe 2030i Biological Safety Cabinets – CTS Series
- Thermo Scientific General Purpose Pro Centrifuges – CTS Series
Cell sorting:
Thermo Scientific laboratory essentials:
- Centrifuge tubes
- ClipTip Pipettes
- Digital vortex mixers
- Aquanex Ultrapure Water Purification System
- Nalgene labware
- Multidrop Combi+ Reagent Dispenser
2. Cell engineering
Gene delivery, modification, vector integration and viral production and purification technologies:
- Applied Biosystems ViralSEQ Lentivirus Proviral DNA Titer Kits
- Gibco CTS HiFi Cas9 Protein and CTS Xenon Genome Editing Buffer Kit
- Gibco CTS Xenon Electroporation System CTS Xenon System
- Invitrogen ViraPower Lentiviral Packaging Mix
- Invitrogen PureLink Expi Endotoxin-Free Plasmid Purification kits
- Gibco CTS LV-Max LentiViral Production System
- Invitrogen Neon NxT Electroporation System
- Thermo Scientific Herasafe 2030i Biological Safety Cabinets – CTS Series
- Thermo Scientific CaptureSelect Affinity Resins
- Thermo Scientific POROS Polish Resins
Thermo Scientific Laboratory essentials:
- ART Wide Bore Tips
- Benchtop centrifuges
- Digital vortex mixers
- Nunc cell factories
- Orbital shakers
- CO2 incubators
- Orion ROSS pH Electrodes
- Orion Versa Star Pro Benchtop pH Meter
3. Cell expansion
The cell expansion process is critical to generating the highest quality CAR T cell product.
- Applied Biosystems MycoSEQ Plus Mycoplasma Detection Kits
- Applied Biosystems SteriSEQ Rapid Sterility Testing Kit
- Gibco CTS OpTmizer One SFM
- Gibco CTS OpTmizer T Cell Expansion SFM (no phenol red or Expansion SFM)
- Gibco CTS OpTmizer Pro SFM
- Gibco PeproGMP recombinant proteins
- Gibco CTS Immune Cell Serum Replacement
- Gibco CTS Growth Factors
- Gibco CTS Synth-a-Freeze Medium
- Gibco CTS Rotea Counterflow Centrifugation System
- Thermo Scientific HyPerforma GXCore controllers with TruBio software
- Thermo Scientific Labtainer(tm) Pro BPC
- Thermo Scientific Fluid Transfer Assembly
- Thermo Scientific CO2 Incubators – CTS Series
- Thermo Scientific Herasafe 2030i Biological Safety Cabinets – CTS Series
Thermo Scientific Laboratory essentials:
4. Characterise
Multiple methods from basic to more advanced characterisation are required throughout the process of manufacturing gene-modified T cells.
- Applied Biosystems SteriSEQ Rapid Sterility Testing Kit
- Invitrogen Attune CytPix Flow Cytometer
- Invitrogen Attune CytKick Max Autosampler
- Invitrogen Countess 3/3FL automated cell counters and slides
- Invitrogen QuantiGene assays
- Thermo Scientific General Purpose Pro Centrifuges – CTS Series
- Thermo Scientific Herasafe 2030i Biological Safety Cabinets – CTS Series
- Ion Torrent Next-generation sequencing systems and assays
Thermo Scientific Laboratory essentials:
Applied Biosystems products:
- ViralSEQ Lentivirus Proviral DNA Titer kits
- ViralSEQ Lentivirus Physical Titer kits
- QuantStudio Real-Time PCR systems
- Real-time PCR reagents and TaqMan assays
- QuantStudio digital PCR Absolute Q
- Absolute Q Universal DNA Digital PCR Master Mix
5. Supply chain and regulatory
- Thermo Scientific Fill Finish Solutions
- Thermo Scientific CryoMed Controlled-Rate Freezer
- Gibco CTS Compleo Fill and Finish System (coming soon in 2025)
Tools and resources
Resources to support best practices when manufacturing gene-modifie T cells.
- Manufacturing support documents, regulatory support files
- European regulatory support files
- Fisher Bioservices cold chain logistics