The human leukocyte antigen (HLA) genes are the most polymorphic region of the human genome. Identifying novel alleles has been laborious and time-consuming for HLA laboratories. With the advancement of next-generation sequencing (NGS), the lab can now access all the bases of all 11 loci of the HLA genes in a single sequencing run. This not only allows a technologist to reliably access known alleles to the fourth field, but it also gives laboratories the ability to discover new clinically relevant alleles.
In this webinar, Dr. Ahmed Mostafa will define what constitutes a novel allele. He will also demonstrate how to identify a novel allele using the TypeStream Visual™ NGS Analysis software (TSV) along with a step-by-step process using TSV to submit the allele to the IPD-IMGT/HLA database.
This webinar is designed to help participants understand:
Dr. Ahmed Mostafa, MD, PhD, F(ACHI)
St. Paul’s Hospital, Saskatoon, Saskatchewan, Canada
Dr. Mostafa acquired his medical degree (MD) and carried his residency in diagnostic laboratory medicine. In December 2013, he graduated from Memorial University of Newfoundland in Canada with a PhD degree in immunology and infectious diseases. Shortly after his graduation, Dr. Mostafa started his postdoctoral training at the University of Calgary in Canada for two years followed by training as a clinical fellow in histocompatibility and immunogenetics at Alberta Precision Labs in Canada. In 2019, Dr. Mostafa was granted the Diplomat of the American Board in Histocompatibility and Immunogenetics (ABHI) and now he is the Clinical Director of the HLA laboratory at St Paul’s Hospital in Saskatoon, Saskatchewan (Canada) and Assistant Professor in the department of pathology and laboratory medicine.
Ahmed Mostafa, MD, PhD, F(ACHI)
St. Paul's Hospital
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