Search
Proteintech
NKCC1 Polyclonal Antibody
{{$productOrderCtrl.translations['antibody.pdp.commerceCard.promotion.promotions']}}
{{$productOrderCtrl.translations['antibody.pdp.commerceCard.promotion.viewpromo']}}
{{$productOrderCtrl.translations['antibody.pdp.commerceCard.promotion.promocode']}}: {{promo.promoCode}} {{promo.promoTitle}} {{promo.promoDescription}}. {{$productOrderCtrl.translations['antibody.pdp.commerceCard.promotion.learnmore']}}
Additional Information:
{{banner.description}}
Product Details
13884-1-AP
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Published species
Mouse,
Pig,
Rat
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
NKCC1 Fusion Protein Ag4991 (759-1150 aa encoded by BC033003)
Conjugate
Form
Liquid
Concentration
0.31 mg/mL
Amount
46.5 µg
Purification
Antigen affinity chromatography
Storage buffer
PBS, pH 7.3, with 50% glycerol
Contains
0.02% sodium azide
Storage conditions
-20°C
Shipping conditions
Wet ice (domestic); Dry ice (international)
Product Specific Information
Immunogen sequence: GSSTQALTY LNALQHSIRL SGVEDHVKNF RPQCLVMTGA PNSRPALLHL VHDFTKNVGL MICGHVHMGP RRQAMKEMSI DQAKYQRWLI KNKMKAFYAP VHADDLREGA QYLMQAAGLG RMKPNTLVLG FKKDWLQADM RDVDMYINLF HDAFDIQYGV VVIRLKEGLD ISHLQGQEEL LSSQEKSPGT KDVVVSVEYS KKSDLDTSKP LSEKPITHKV EEEDGKTATQ PLLKKESKGP IVPLNVADQK LLEASTQFQK KQGKNTIDVW WLFDDGGLTL LIPYLLTTKK KWKDCKIRVF IGGKINRIDH DRRAMATLLS KFRIDFSDIM VLGDINTKPK KENIIAFEEI IEPYRLHEDD KEQDIADKMK EDEPWRITDN ELELYKTKFY EPC (759-1150 aa encoded by B C033003)
Target Information
NKCC1 mediates sodium and chloride transport and reabsorption. NKCC1 is a membrane protein and is important in maintaining proper ionic balance and cell volume. NKCC1 is an electrically silent transporter system that mediates sodium and chloride reabsorption. Further, NKCC1 plays a vital role in the regulation of ionic balance and cell volume and is phosphorylated in response to DNA damage. Three transcript variants encoding two different isoforms have been found for NKCC1. Diseases associated with SLC12A2 include Basosquamous Carcinoma and Metatypical Basal Cell Carcinoma.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Bioinformatics
Protein Aliases: Basolateral Na-K-Cl symporter; BSC2; bumetanide-sensitive cotransporter type 2; bumetanide-sensitive sodium-(potassium)-chloride cotransporter 1; Bumetanide-sensitive sodium-(potassium)-chloride cotransporter 2; cation-chloride cotransporter; hNKCC1; membrane electrolyte transporter; mNKCC1; Na-K-2Cl cotransporter 1; protein phosphatase 1, regulatory subunit 141; sodium/potassium/chloride cotransporters; sodium/potassium/chloride transporters; solute carrier family 12 (sodium/potassium/chloride transporter), member 2; solute carrier family 12 (sodium/potassium/chloride transporters), member 2; Solute carrier family 12 member 2; solute carrier family 12, member 2
Gene Aliases: 9330166H04Rik; BSC; BSC-2; BSC2; CCC1; hNKCC1; KILQS; mBSC2; NKCC1; PPP1R141; SLC12A2; sy-ns
UniProt ID: (Human) P55011, (Mouse) P55012
Entrez Gene ID: (Human) 6558, (Rat) 83629, (Mouse) 20496
protein binding
sodium:potassium:chloride symporter activity
ammonium transmembrane transporter activity
potassium ion transmembrane transporter activity
symporter activity
cation:chloride symporter activity
protein kinase binding
transmembrane transporter activity
metal ion transmembrane transporter activity
chaperone binding
Hsp90 protein binding
transporter activity
secondary carrier transporter
ion transport
potassium ion transport
sodium ion transport
chloride transport
cellular sodium ion homeostasis
cell volume homeostasis
hyperosmotic response
gamma-aminobutyric acid signaling pathway
T cell chemotaxis
cellular potassium ion homeostasis
transepithelial chloride transport
cellular chloride ion homeostasis
maintenance of blood-brain barrier
sodium ion transmembrane transport
cellular response to potassium ion
positive regulation of cell volume
chloride ion homeostasis
potassium ion homeostasis
sodium ion homeostasis
transmembrane transport
negative regulation of vascular wound healing
transepithelial ammonium transport
ammonium transmembrane transport
inorganic anion import across plasma membrane
inorganic cation import across plasma membrane
sodium ion import across plasma membrane
regulation of spontaneous synaptic transmission
transport across blood-brain barrier
chloride transmembrane transport
positive regulation of aspartate secretion
regulation of matrix metallopeptidase secretion
potassium ion import across plasma membrane
cellular response to chemokine
aging
ammonium transport
multicellular organism growth
detection of mechanical stimulus involved in sensory perception of sound
branching involved in mammary gland duct morphogenesis
mammary duct terminal end bud growth
transport
organic cation transport
Disclaimer
Clicking the images or links will redirect you to a website hosted by BenchSci that provides third-party scientific content. Neither the content nor the BenchSci technology and processes for selection have been evaluated by us; we are providing them as-is and without warranty of any kind, including for use or application of the Thermo Fisher Scientific products presented.
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
Learn more
We're here to help
Get expert recommendations for common problems or connect directly with an on staff expert for technical assistance related to applications, equipment and general product use.
Contact tech support