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Proteintech
USP15 Polyclonal Antibody
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Product Details
14354-1-AP
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Published species
Bovine,
Mouse
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
USP15 Fusion Protein Ag5703 (1-235 aa encoded by BC020688)
Conjugate
Form
Liquid
Concentration
0.44 mg/mL
Amount
66 µg
Purification
Antigen affinity chromatography
Storage buffer
PBS, pH 7.3, with 50% glycerol
Contains
0.02% sodium azide
Storage conditions
-20°C
Shipping conditions
Wet ice (domestic); Dry ice (international)
Product Specific Information
Immunogen sequence: MAEGGAADL DTQRSDIATL LKTSLRKGDT WYLVDSRWFK QWKKYVGFDS WDKYQMGDQN VYPGPIDNSG LLKDGDAQSL KEHLIDELDY ILLPTEGWNK LVSWYTLMEG QEPIARKVVE QGMFVKHCKV EVYLTELKLC ENGNMNNVVT RRFSKADTID TIEKEIRKIF SIPDEKETRL WNKYMSNTFE PLNKPDSTIQ DAGLYQGQVL VIEQKNEDGT WPRGPSTPKK PLEQSC (1-235 aa encoded by B C020688)
Target Information
Modification of target proteins by ubiquitin participates in a wide array of biological functions. Proteins destined for degradation or processing via the 26 S proteasome are coupled to multiple copies of ubiquitin. However, attachment of ubiquitin or ubiquitin-related molecules may also result in changes in subcellular distribution or modification of protein activity. An additional level of ubiquitin regulation, deubiquitination, is catalyzed by proteases called deubiquitinating enzymes, which fall into four distinct families. Ubiquitin C-terminal hydrolases, ubiquitin-specific processing proteases (USPs),1 OTU-domain ubiquitin-aldehyde-binding proteins, and Jab1/Pad1/MPN-domain-containing metallo-enzymes. Among these four families, USPs represent the most widespread and represented deubiquitinating enzymes across evolution. USPs tend to release ubiquitin from a conjugated protein. They display similar catalytic domains containing conserved Cys and His boxes but divergent N-terminal and occasionally C-terminal extensions, which are thought to function in substrate recognition, subcellular localization, and protein-protein interactions.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Bioinformatics
Protein Aliases: Deubiquitinating enzyme 15; deubiquitinating enzyme Ubp109; granule cell antiserum positive 18; MGC131982; MGC149838; MGC74854; protease; Ubiquitin carboxyl-terminal hydrolase 15; Ubiquitin carboxyl-terminal hydrolase of 109 kDa; ubiquitin specific protease 15; Ubiquitin thioesterase 15; ubiquitin thiolesterase 15; ubiquitin-specific cysteine protease; Ubiquitin-specific-processing protease 15; unnamed protein product; Unph-2; Unph4
Gene Aliases: 4921514G19Rik; AI327321; E430033I05Rik; Gcap18; KIAA0529; Ubp109; UNPH-2; UNPH4; USP15
UniProt ID: (Human) Q9Y4E8, (Mouse) Q8R5H1, (Rat) Q9R085
Entrez Gene ID: (Human) 9958, (Mouse) 14479, (Rat) 171329
catalytic activity
cysteine-type endopeptidase activity
thiol-dependent ubiquitin-specific protease activity
transforming growth factor beta receptor binding
protein binding
peptidase activity
cysteine-type peptidase activity
hydrolase activity
identical protein binding
SMAD binding
ubiquitinated histone binding
ubiquitinyl hydrolase activity
Lys48-specific deubiquitinase activity
thiol-dependent ubiquitinyl hydrolase activity
cysteine protease
proteolysis
transforming growth factor beta receptor signaling pathway
protein deubiquitination
BMP signaling pathway
negative regulation of transforming growth factor beta receptor signaling pathway
monoubiquitinated protein deubiquitination
positive regulation of I-kappaB kinase/NF-kappaB signaling
regulation of RNA metabolic process
transcription elongation-coupled chromatin remodeling
positive regulation of RIG-I signaling pathway
regulation of intrinsic apoptotic signaling pathway in response to osmotic stress by p53 class mediator
negative regulation of antifungal innate immune response
protein K27-linked deubiquitination
ubiquitin-dependent protein catabolic process
histone H2B conserved C-terminal lysine deubiquitination
proteasome-mediated ubiquitin-dependent protein catabolic process
pathway-restricted SMAD protein phosphorylation
regulation of proteasomal protein catabolic process
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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