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CD307d (FcRL4) Monoclonal Antibody (413D12), APC, eBioscience™
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FIGURE: 1 / 6
CD307d (FcRL4) Antibody (17-3079-42) in Flow
Normal human peripheral blood cells were unstimulated (left) or stimulated overnight with Human CD40 Ligand Recombinant Protein, Human IL-2 Recombinant Protein, and CpG 2006 (right). Cells were then stained with CD20 Monoclonal Antibody, FITC (Product # 11-0209-42) and CD307d (FcRL4) Monoclonal Antibody, APC. Viable cells in the lymphocyte gate were used for analysis, as determined by Fixable Viability Dye eFluor 450 (Product # 65-0863-18).
Please note: We are reviewing Western blot images included in the antibody testing data in our catalog, including those provided by third parties. Unless expressly labeled or annotated as “raw-unedited”, Western blot images included in the antibody testing data in our catalog may have been edited, optimized or otherwise adjusted for presentation.
Product Details
17-3079-42
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human
Host/Isotype
Mouse
/ IgG2b, kappa
Recommended Isotype Control
Class
Monoclonal
Type
Antibody
Clone
413D12
Conjugate
APC
APC
APC
Excitation/Emission Max
651/660 nm
View spectra
Form
Liquid
Concentration
5 µL/Test
Purification
Affinity chromatography
Storage buffer
PBS, pH 7.2, with BSA
Contains
0.09% sodium azide
Storage conditions
4°C, store in dark, DO NOT FREEZE!
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Product Specific Information
Description: The 413D12 monoclonal antibody reacts with human CD307d, which is also known as FcRL4, Fc receptor-like 4, FcRH4, IRTA4, or IGFP2. CD307d is an inhibitory receptor that is highly expressed on a subset of memory B cells resident in epithelial tissues and marginal zones of mucosal lymphoid tissues such as tonsils. CD307d has been shown to recruit the phosphatase SHP-1, thereby acting as an inhibitory receptor in B cells. CD307d is homologous to FcgammaRI and specifically binds IgA. To date, CD307d is the only known inhibitory receptor for IgA. Expression of CD307d is increased on memory B cells from patients with chronic infections such as HIV, suggesting that enhanced expression of inhibitory receptors, such as CD307d, may contribute to the inefficiency of antibody responses against HIV.
Applications Reported: This 413D12 antibody has been reported for use in flow cytometric analysis.
Applications Tested: This 413D12 antibody has been pre-diluted and tested by flow cytometric analysis of stimulated normal human peripheral blood cells and transfected 293T cells. This may be used at 5 µL (0.25 µg) per test. A test is defined as the amount (µg) of antibody that will stain a cell sample in a final volume of 100 µL. Cell number should be determined empirically but can range from 10^5 to 10^8 cells/test.
Excitation: 633-647 nm; Emission: 660 nm; Laser: Red Laser
Target Information
This gene encodes a member of the immunoglobulin receptor superfamily and is one of several Fc receptor-like glycoproteins clustered on the long arm of chromosome 1. The encoded protein has four extracellular C2-type immunoglobulin domains, a transmembrane domain and a cytoplasmic domain that contains three immune-receptor tyrosine-based inhibitory motifs. This protein may play a role in the function of memory B-cells in the epithelia. Aberrations in the chromosomal region encoding this gene are associated with non-Hodgkin lymphoma and multiple myeloma.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: fc receptor homolog 4; fcR-like protein 4; hIFGP2; IFGP family protein 2; Ig-like superfamily receptor; immune receptor translocation-associated protein 1; immunoglobulin superfamily Fc receptor, gp42; immunoglobulin superfamily receptor translocation associated 1; IRTA1a; IRTA1b; IRTA1c; MGC150522; MGC150523
Gene Aliases: CD307d; FCRH4; IGFP2; IRTA1
UniProt ID: (Human) Q96PJ5
Entrez Gene ID: (Human) 83417
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