Thermo Scientific Pierce Sulfo-GMBS is a water-soluble amine-to-sulfhydryl crosslinker that contains NHS-ester and maleimide reactive groups at opposite ends of a short spacer arm (7.3 angstroms).
Features of Sulfo-GMBS:
• Reactive groups: sulfo-NHS ester and maleimide • Reactive towards: amino and sulfhydryl groups • Non-cleavable • Water-soluble (compare to GMBS) • Has a low potential for illiciting crosslinker immune response, ensuring that the primary response to the antigen-carrier protein conjugate is not diluted by a response against a determinant on the crosslinker • GMBS and Sulfo-GMBS are reported to be less immunogenic than SMCC
Product References:
Crosslinker Application Guide -- search for recent literature references for this product