GMBS (N-γ-maleimidobutyryl-oxysuccinimide ester)

Catalog number: 22309

Thermo Scientific™  Related applications: Protein Labeling & Crosslinking

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Thermo Scientific Pierce GMBS is an amine-to-sulfhydryl crosslinker that contains NHS-ester and maleimide reactive groups at opposite ends of a short spacer arm (7.3 angstroms).

Features of GMBS:

Reactive groups: NHS ester and maleimide
Reactive toward: amino and sulfhydryl groups
• C4-homolog of aliphatic spacer series which includes AMAS, BMPS, GMBS and EMCS
• NHS ester end couples with primary amines at pH 7-9 to form stable amide bonds
• Maleimides react with -SH groups at pH 6.5-7.5, forming stable thioether linkages
• Non-cleavable
• Water-insoluble (dissolve first in DMF or DMSO); compare to Sulfo-GMBS
• Short aliphatic spacer has low potential for eliciting an immune response

Product References:
Crosslinker Application Guide -- search for recent literature references for this product
For Research Use Only. Not for use in diagnostic procedures.


Spacer: Short
Solubility: DMSO (Dimethylsulfoxide), DMF (Dimethylformamide)
Product Size: 50 mg
Labeling Method: Chemical Labeling
Crosslinker Type: Heterobifunctional

Contents & storage

Store at 4°C.


Manuals & protocols