AMAS (N-α-maleimidoacet-oxysuccinimide ester)

      AMAS (N-α-maleimidoacet-oxysuccinimide ester)

      Catalog number:  22295

      Thermo Scientific™  Related applications: Protein Labeling & Crosslinking

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      Description

      Thermo Scientific Pierce AMAS is an amine-to-sulfhydryl crosslinker that contains NHS-ester and maleimide reactive groups at opposite ends of a very short spacer arm (4.4 angstroms).

      Features of AMAS:

      • Reactive groups: NHS ester and maleimide
      • Reactive towards: amino and sulfhydryl groups
      • Shortest of aliphatic spacer series which includes AMAS, BMPS, GMBS and EMCS
      • NHS ester end couples with primary amines at pH 7-9, forming stable amide bonds
      • Maleimide reacts with -SH groups at pH 6.5-7.5, forming stable thioether linkages
      • Non-cleavable
      • Water-insoluble (dissolve first in DMF or DMSO)
      • Very short aliphatic spacer has low potential for eliciting an immune response
      For Research Use Only. Not for use in diagnostic procedures.

      Specifications

      Crosslinker Type: Heterobifunctional
      Labeling Method: Chemical Labeling
      Product Line: Pierce™
      Product Size: 50 mg
      Solubility: DMF (Dimethylformamide), DMSO (Dimethylsulfoxide)
      Spacer: Short

      Contents & storage

      Store desiccated at 4°C.

      Documents

      Manuals & protocols