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Gibco
Human MIP-1 beta (CCL4) Recombinant Protein, PeproTech®
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Product Details
300-09-50UG
Applications
Tested Dilution
Publications
Product Specifications
Species
Human
Published species
Bacteria,
Hamster,
Human,
Mouse,
Pig
Expression System
E. coli
Amino acid sequence
APMGSDPPTA CCFSYTARKL PHNFVVDYYE TSSLCSQPAV VFQTKRGKQV CADPSESWVQ EYVYDLELN
Molecular weight
7.6 kDa
Class
Recombinant
Type
Protein
Purity
≥ 98% by SDS-PAGE gel and HPLC analyses.
Endotoxin concentration
<1 EU/µg
Activity
Determined by its ability to chemoattract human blood monocytes using a concentration range of 5.0-20.0 ng/ml.
Conjugate
Unconjugated
Unconjugated
Unconjugated
Form
Lyophilized
Amount
50 µg
Purification
purified
Contains
no preservative
Storage conditions
-20°C
Shipping conditions
Ambient
Product Specific Information
Recombinant Human MIP-1beta is a 7.6 kDa protein containing 69 amino acid residues, including the four highly conserved cysteine residues present in CC chemokines.
This product is shipped at ambient temperature. For storage, handling and reconstitution information, please see the lot-specific Certificate of Analysis
Target Information
CCL4 (macrophage inflammatory protein 1-beta, MIP1B) belongs to the intercrine beta (chemokine CC) family. Functionally, CCL4 is involved in chemotactic and proinflammatory effects, and homeostasis. CCL4 is produced by macrophages upon stimulation by bacterial endotoxins. CCL4 recruits and stimulates various inflammatory cells at sites of inflammation. CCL4 is produced by lymphocytes, macrophages and dendritic cells. Both CCL4 and the related protein CCL3 participate in the host response to invading bacterial, viral, parasite and fungal pathogens by regulating the trafficking and activation state of selected subgroups of inflammatory cells. While both CCL4 and CCL3 exert similar effects on monocytes, their effect on lymphocytes differ, with CCL4 selectively attracting CD4+ lymphocytes and CCL3 selectively attracting CD8+ lymphocytes. Additionally, both have been shown to be potent chemoattractants for B cells, eosinophils and dendritic cells. The processed form of CCL4 can induce down-modulation of surface expression of the chemokine receptor CCR5, thus inhibiting the CCR5-mediated entry of HIV-1 in T cells. CCL4 binds with high affinity to CCR5 receptors.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Bioinformatics
Protein Aliases: act-2 protein precursor; CCL4; chemokine (C-C motif) ligand 4; G-26 T-lymphocyte-secreted protein; LAG-1; lymphocyte activation gene 1 protein; macrophage inflammatory protein 1-beta; MGC104418; MGC126025; MGC126026; MIP-1-beta(1-69); MIP1-beta; MIP1beta; PAT 744; RP23-320E6.8; secreted protein G-26; SIS-gamma; small inducible cytokine A4 (homologous to mouse Mip-1b); T-cell activation protein 2
Gene Aliases: ACT2; AT744.1; G-26; HC21; LAG-1; LAG1; MIP-1-beta; MIP1B; MIP1B1; SCYA2; SCYA4
UniProt ID: (Human) P13236
Entrez Gene ID: (Human) 6351
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