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Invitrogen
Claudin 1 Monoclonal Antibody (2H10D10)
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FIGURE: 1 / 71
Claudin 1 Antibody (37-4900) in ICC/IF
Immunofluorescent analysis of Claudin-1 was done on 90% confluent log phase CaCo-2 cells. The cells were fixed with 4% paraformaldehyde for 15 minutes; permeabilized with 0.25% Triton™ X-100 for 10 minutes followed by blocking with 5% BSA for 1 hour at room temperature. The cells were incubated with Claudin-1 Mouse Monoclonal Antibody (Product # 37-4900) at 1 µg/mL in 1% BSA and incubated for 3 hours at roo... View More
Product Details
37-4900
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Dog,
Human,
Mouse,
Rat
Published species
Chicken,
Dog,
Human,
Mouse,
Pig,
Rabbit,
Rat,
Rhesus monkey
Host/Isotype
Mouse
/ IgG1
Class
Monoclonal
Type
Antibody
Clone
2H10D10
Immunogen
Synthetic peptide derived from the C-terminal region of the human and mouse claudin-1 proteins
Conjugate
Form
Liquid
Concentration
0.5 mg/mL
Purification
Protein A
Storage buffer
PBS, pH 7.4
Contains
0.1% sodium azide
Storage conditions
Maintain refrigerated at 2-8°C for up to 1 month. For long term storage store at -20°C
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Product Specific Information
Reactivity has been confirmed with human Caco-2 and canine MDCK cell lysates, mouse kidney and intestinal lysates, frozen mouse intestine (jejunum) tissue, and rat kidney homogenates.
This antibody is specific for the C-terminal region of the claudin-1 protein. On western blots, it identifies the target band at ~22 kDa.
Target Information
Claudin-1 is a member of the transmembrane protein family claudins located in cell-cell tight junctions and it acts as a co-receptor for HCV entry into hepatic cells. Claudins are abundant in luminal epithelial sheets where they maintain epithelial cell polarity. Claudin-1 is expressed in most tissues such as bladder, fallopian tube, liver, pancreas, prostate, and skin.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Bioinformatics
Protein Aliases: Claudin-1; CLDN1; Senescence-associated epithelial membrane protein; senescence-associated epithelial membrane protein 1; tight junction transmembrane protein; unnamed protein product
Gene Aliases: AI596271; CLD1; CLDN1; ILVASC; SEMP1; UNQ481/PRO944
UniProt ID: (Human) O95832, (Rat) P56745, (Mouse) O88551
Entrez Gene ID: (Human) 9076, (Dog) 608207, (Rat) 65129, (Mouse) 12737
cell adhesion
establishment of blood-nerve barrier
response to toxic substance
calcium-independent cell-cell adhesion via plasma membrane cell-adhesion molecules
positive regulation of cell migration
response to lipopolysaccharide
cell junction maintenance
maintenance of blood-brain barrier
cell-cell junction organization
response to ethanol
viral entry into host cell
protein oligomerization
positive regulation of epithelial cell proliferation involved in wound healing
establishment of skin barrier
xenobiotic transport across blood-nerve barrier
response to interleukin-18
bicellular tight junction assembly
cellular response to lead ion
cellular response to interferon-gamma
cellular response to tumor necrosis factor
response to dexamethasone
cellular response to transforming growth factor beta stimulus
positive regulation of wound healing
establishment of endothelial intestinal barrier
liver regeneration
positive regulation of bicellular tight junction assembly
cellular response to butyrate
Disclaimer
Clicking the images or links will redirect you to a website hosted by BenchSci that provides third-party scientific content. Neither the content nor the BenchSci technology and processes for selection have been evaluated by us; we are providing them as-is and without warranty of any kind, including for use or application of the Thermo Fisher Scientific products presented.
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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