Search
Invitrogen
Claudin 1 Monoclonal Antibody (2H10D10), Alexa Fluor™ 488
{{$productOrderCtrl.translations['antibody.pdp.commerceCard.promotion.promotions']}}
{{$productOrderCtrl.translations['antibody.pdp.commerceCard.promotion.viewpromo']}}
{{$productOrderCtrl.translations['antibody.pdp.commerceCard.promotion.promocode']}}: {{promo.promoCode}} {{promo.promoTitle}} {{promo.promoDescription}}. {{$productOrderCtrl.translations['antibody.pdp.commerceCard.promotion.learnmore']}}
Additional Information:
{{banner.description}}
Product Details
374988
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Dog,
Human,
Mouse,
Rat
Published species
Human
Host/Isotype
Mouse
/ IgG1
Class
Monoclonal
Type
Antibody
Clone
2H10D10
Immunogen
Synthetic peptide derived from the C-terminal region of the human and mouse claudin-1 proteins
Conjugate
Excitation/Emission Max
499/520 nm
View spectra
Form
Liquid
Concentration
0.5 mg/mL
Purification
Protein A
Storage buffer
PBS, pH 7.4, with 4.0mg/mL BSA
Contains
0.1% sodium azide
Storage conditions
4°C, store in dark
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Product Specific Information
Reactivity has been confirmed with human Caco-2 and canine MDCK cell lysates, mouse kidney and intestinal lysates, frozen mouse intestine (jejunum) tissue, and rat kidney homogenates.
Target Information
Claudin-1 is a member of the transmembrane protein family claudins located in cell-cell tight junctions and it acts as a co-receptor for HCV entry into hepatic cells. Claudins are abundant in luminal epithelial sheets where they maintain epithelial cell polarity. Claudin-1 is expressed in most tissues such as bladder, fallopian tube, liver, pancreas, prostate, and skin.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Bioinformatics
Protein Aliases: Claudin-1; CLDN1; Senescence-associated epithelial membrane protein; senescence-associated epithelial membrane protein 1; tight junction transmembrane protein; unnamed protein product
Gene Aliases: AI596271; CLD1; CLDN1; ILVASC; SEMP1; UNQ481/PRO944
UniProt ID: (Human) O95832, (Rat) P56745, (Mouse) O88551
Entrez Gene ID: (Human) 9076, (Dog) 608207, (Rat) 65129, (Mouse) 12737
cell adhesion
establishment of blood-nerve barrier
response to toxic substance
calcium-independent cell-cell adhesion via plasma membrane cell-adhesion molecules
positive regulation of cell migration
response to lipopolysaccharide
cell junction maintenance
maintenance of blood-brain barrier
cell-cell junction organization
response to ethanol
viral entry into host cell
protein oligomerization
positive regulation of epithelial cell proliferation involved in wound healing
establishment of skin barrier
xenobiotic transport across blood-nerve barrier
response to interleukin-18
bicellular tight junction assembly
cellular response to lead ion
cellular response to interferon-gamma
cellular response to tumor necrosis factor
response to dexamethasone
cellular response to transforming growth factor beta stimulus
positive regulation of wound healing
establishment of endothelial intestinal barrier
liver regeneration
positive regulation of bicellular tight junction assembly
cellular response to butyrate
Disclaimer
Clicking the images or links will redirect you to a website hosted by BenchSci that provides third-party scientific content. Neither the content nor the BenchSci technology and processes for selection have been evaluated by us; we are providing them as-is and without warranty of any kind, including for use or application of the Thermo Fisher Scientific products presented.
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
Learn more
We're here to help
Get expert recommendations for common problems or connect directly with an on staff expert for technical assistance related to applications, equipment and general product use.
Contact tech support