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Invitrogen

Phospho-INSR (Tyr1158) Recombinant Rabbit Monoclonal Antibody (8H20L22)

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Phospho-INSR (Tyr1158) Recombinant Rabbit Monoclonal Antibody (8H20L22)

Product Details

701070

Applications
Tested Dilution
Publications

Western Blot (WB)

1-3 µg/mL
-
Product Specifications

Species Reactivity

Human

Host/Isotype

Rabbit / IgG

Expression System

Expi293

Class

Recombinant Monoclonal

Type

Antibody

Clone

8H20L22

Immunogen

Phosphopeptide corresponding to amino acids 1153-1162 of human insulin receptor
3D Epitope / Immunogen

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

0.5 mg/mL

Amount

100 µg

Purification

Protein A

Storage buffer

PBS

Contains

0.09% sodium azide

Storage conditions

Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.

Shipping conditions

Wet ice

RRID

AB_2532371

Product Specific Information

This antibody is predicted to react with non-human primate, mouse and rat based on sequence homology.

Intact IgG appears on a non-reducing gel as ~150 kDa band and upon reduction generating a ~25 kDa light chain band and a ~50 kDa heavy chain.

Recombinant rabbit monoclonal antibodies are produced using in vitro expression systems. The expression systems are developed by cloning in the specific antibody DNA sequences from immunoreactive rabbits. Then, individual clones are screened to select the best candidates for production. The advantages of using recombinant rabbit monoclonal antibodies include: better specificity and sensitivity, lot-to-lot consistency, animal origin-free formulations, and broader immunoreactivity to diverse targets due to larger rabbit immune repertoire.

Target Information

INSR is a receptor tyrosine kinase. Binding of insulin to the extracellular domain of INSR stimulates glucose uptake. INSR and IGF-1 receptors share major structural and functional similarity. The earliest cellular response to insulin stimulation is autophosphorylation of tyrosine in INSR. In humans, the INSR gene is located on chromosome 19. Defects in INSR are the cause of various insulin resistance syndromes and IGF-1R defects may also cause some forms of growth retardation.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

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Bioinformatics

Protein Aliases: CD 220; CD220; CD220 antigen; CD220 beta; CD221; HHF 5; IGF-I receptor; Insulin receptor; insulin receptor precursor; IR; IR 1; IR beta; IR-1; IR1; unnamed protein product

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Gene Aliases: CD220; HHF5; INSR

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UniProt ID: (Human) P06213

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Entrez Gene ID: (Human) 3643

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Function(s)
nucleotide binding beta-amyloid binding protein kinase activity protein tyrosine kinase activity transmembrane receptor protein tyrosine kinase activity insulin-activated receptor activity insulin-like growth factor receptor binding structural molecule activity protein binding ATP binding GTP binding kinase activity transferase activity protein domain specific binding protein kinase activator activity insulin-like growth factor I binding insulin-like growth factor II binding cargo receptor activity identical protein binding phosphatidylinositol 3-kinase binding insulin binding insulin receptor substrate binding macromolecular complex binding PTB domain binding
Process(es)
positive regulation of receptor internalization heart morphogenesis regulation of glycogen biosynthetic process regulation of transcription, DNA-templated receptor-mediated endocytosis transmembrane receptor protein tyrosine kinase signaling pathway G-protein coupled receptor signaling pathway learning memory positive regulation of cell proliferation insulin receptor signaling pathway epidermis development male gonad development organ morphogenesis regulation of gene expression positive regulation of macromolecule biosynthetic process regulation of glucose metabolic process male sex determination adrenal gland development positive regulation of cell migration exocrine pancreas development receptor internalization cellular response to insulin stimulus glucose homeostasis positive regulation of I-kappaB kinase/NF-kappaB signaling positive regulation of protein complex disassembly positive regulation of MAPK cascade positive regulation of nitric oxide biosynthetic process positive regulation of glycogen biosynthetic process positive regulation of glycolytic process positive regulation of mitotic nuclear division positive regulation of transcription, DNA-templated regulation of embryonic development positive regulation of glucose import viral entry into host cell protein autophosphorylation animal organ development positive regulation of developmental growth system development positive regulation of cellular component organization regulation of multicellular organismal process positive regulation of meiotic cell cycle positive regulation of protein kinase B signaling positive regulation of respiratory burst cellular response to growth factor stimulus dendritic spine maintenance beta-amyloid clearance transport across blood-brain barrier neuron projection maintenance regulation of female gonad development
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