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5-Fluoruracil, 99 %, Thermo Scientific Chemicals
5-Fluoruracil, 99 %, Thermo Scientific Chemicals
5-Fluoruracil, 99 %, Thermo Scientific Chemicals
Thermo Scientific Chemicals

5-Fluoruracil, 99 %, Thermo Scientific Chemicals

CAS: 51-21-8 | C4H3FN2O2 | 130.08 g/mol
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Katalognummer A13456.06
auch als A13456-06 bezeichnet
Preis (EUR)
47,65
Exklusiv online
52,70
Ersparnis 5,05 (10%)
Each
Menge:
5 g
Großbestellung oder individuelle Größe anfordern
Preis (EUR)
47,65
Exklusiv online
52,70
Ersparnis 5,05 (10%)
Each
Chemikalien-Kennzeichnungen
CAS51-21-8
IUPAC Name5-fluoro-1,2,3,4-tetrahydropyrimidine-2,4-dione
Molecular FormulaC4H3FN2O2
InChI KeyGHASVSINZRGABV-UHFFFAOYSA-N
SMILESFC1=CNC(=O)NC1=O
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SpecificationsSpecification SheetDatenblatt
FormCrystalline powder
Appearance (Color)White to pale cream
Assay from Suppliers CofA≥98.5%
5-Fluorouracil is used as an antitumor agent in the treatment of anal, breast, colorectal, oesophageal, stomach, pancreatic and skin cancers. It finds application as a suicide inhibitor due to its irreversible inhibition of thymidylate synthase. It is also used in the treatment of actinic keratoses and bowen's disease. Further, it serves as a potent antineoplastic agent in clinical use. In addition to this, it acts as a DNA synthesis inhibitor.

This Thermo Scientific Chemicals brand product was originally part of the Alfa Aesar product portfolio. Some documentation and label information may refer to the legacy brand. The original Alfa Aesar product / item code or SKU reference has not changed as a part of the brand transition to Thermo Scientific Chemicals.

Löslichkeit
Löslich in Dimethylformamid, Dimethylsulfoxid, Methanol, heißem Wasser, Ammoniumhydroxid, Natriumhydroxid, Ethanol und Wasser.

Hinweise
Kühl lagern. Nicht kompatibel mit starken Oxidationsmitteln und starken Basen.
RUO – Research Use Only

Allgemeine Referenzen:

  1. Antineoplastisches Mittel Nicht zum Einsatz für Arzneimittel.
  2. Cosco, D.; Paolino, D.; Maiuolo, J.; Di Marzio, L.; Carafa, M.; Ventura, C. A.; Fresta, M. Ultradeformable liposomes as multidrug carrier of resveratrol and 5-fluorouracil for their topical delivery. Int. J. Pharm. 2015, 489 (1-2), 1-10.
  3. Wu, X.; He, C.; Wu, Y.; Chen, X. Synergistic therapeutic effects of Schiff's base cross-linked injectable hydrogels for local co-delivery of metformin and 5-fluorouracil in a mouse colon carcinoma model. Biomaterials 2016, 75, 148-162.