Invitrogen™

PIK3CA E545K/PIK3R1 (p110 alpha E545K/p85 alpha) Recombinant Human Protein

Catalog number: A31083
Invitrogen™

PIK3CA E545K/PIK3R1 (p110 alpha E545K/p85 alpha) Recombinant Human Protein

Catalog number: A31083
Catalog Number
A31083
Unit Size
20 µg
Price (USD)
738.00
Your Price:
Availability
***
Quantity
Catalog Number
Unit Size
100 µg
Price (USD)
2,115.00
Your Price:
Availability
***
Quantity
Catalog Number
Unit Size
1 mg
Price (USD)
6,570.00
Your Price:
Availability
***
Quantity
Catalog NumberUnit SizePrice (USD)AvailabilityQuantity
A3108320 µg
738.00
Your Price:
***
A32909100 µg
2,115.00
Your Price:
***
A333941 mg
6,570.00
Your Price:
***
Product Overview
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This PIK3CA E545K/PIK3R1 (p110 alpha E545K/p85 alpha) recombinant human protein (full length) was expressed in insect cells. PIK3CA (E545K)/PIK3R1 lipid kinase (p110 alpha E545K/p85 alpha) consists of a 110 kDa catalytic subunit and an 85 kDa regulatory subunit. A number of isoforms of the 110 kDa catalytic subunit and the 85 kDa regulatory subunit exist in cells. The PIK3CA catalytic subunit is frequently mutated or amplified in a variety of cancers including ovarian and colon and this protein is one of the PI3K mutants. PIK3CA gene copy number is increased in over 30% of ovarian cancers and this leads to increased PI3-kinase activity. Furthermore, the activity of PIK3CA is essential for vascular development and inactivation of PIK3Ca leads to severe defects in angiogenic sprouting and vascular remodeling. PIK3CA E545K/PIK3R1 (p110 alpha E545K/p85 alpha) recombinant human protein is also available in our SelectScreen™ Kinase Profiling Service.

• Validated for use with the Adapta™ assay
• Available in multiple pack sizes for convenient use
• Also available in our SelectScreen Kinase Profiling Service

For Research Use Only. Not for use in diagnostic procedures.

Specifications

Accession Number
PIK3CA E455K: NP_006209.2, PIK3R1(p110a) : NP_852664.1
Shipping Condition
Dry Ice
Expression System
Insect
Form
Liquid
Protein Form
Full Length, Recombinant, Active, Mutant
Species
Human
Validated Application
Kinase Assay
Molecular Weight
125.4/84.7 kDa
Quantity
20 µg
KinaseFamily
PI3 Kinase
Protein Length
Full Length
Recombinant
Yes
Protein Tag
His Tag

Contents & Storage

Storage Buffer: 50 mM sodium phosphate, pH 7.0, 300 mM NaCl, 150 mM imidazole, 0.1 mM PMSF, 0.25 mM DTT, 25% glycerol.

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Frequently asked questions (FAQs)

Citations & References