This CDK18/cyclin Y recombinant human protein (CDK18: full length, cyclin Y: 2–end) was expressed in insect cells. CDK18/cyclin Y serine/threonine kinase or cyclin-dependent kinase 18 belongs to the cdc2/cdkx subfamily of kinases. CDK18/cyclin Y is thought to play a role in terminally differentiated neurons and it contains an N-terminal extension relative to CDC2. CDK18/cyclin Y is expressed in a variety of human cell lines and tissues. Elevation in the protein levels of CDK18/cyclin Y in the temporal cortex of Alzheimer's disease relative to control brains has been observed. It is proposed that CDK18/cyclin Y is a paired helical filaments-associated kinase that modulates tau phosphorylation. CDK18/cyclin Y recombinant human protein is also available in our SelectScreen™ Kinase Profiling Service.
• Validated for use with the Z’-LYTE™ assay • Available in multiple pack sizes for convenient use • Also available in our SelectScreen Kinase Profiling Service
For Research Use Only. Not for use in diagnostic procedures.
CDK18: AAH11526, CyclinY: NP_659449
Recombinant, Active, Catalytic
CDKs and CHKs
CDK18: Full Length, Cyclin Y: 2 - end
Contents & Storage
Storage Buffer: 50 mM Tris-HCl, pH 7.5, 150 mM NaCl, 10 mM glutathione, 0.1 mM EDTA, 0.25 mM DTT, 0.1 mM PMSF, 25% glycerol.