Search Thermo Fisher Scientific
Search Thermo Fisher Scientific
For maximum recovery please spin prior to use. Unless noted below, aliquots of the 5 µg, 10 µg and 20 µg sizes of kinase are not recommended as materials can be used in original packaging until exhausted. For larger sizes, the number of freeze/thaws may be reduced by preparing aliquots, aliquots below 20 µL are not recommended. Please never store a kinase diluted. If properly stored at -80C, this product is guaranteed for 6 months from date of purchase.
This CSNK1A1L recombinant human protein (full length) was expressed in insect cells.
CSNK1A1L recombinant human protein is also available in our SelectScreen™ Kinase Profiling Service.
• Validated for use with the Z'-LYTE™ assay
• Available in multiple pack sizes for convenient use
• Also available in our SelectScreen Kinase Profiling Service
Protein Form: Full Length, Recombinant, Active
CSNK1A1L serine/threonine kinase or CK1-alpha dynamically associates with the CBM complex upon T cell receptor engagement to participate in cytokine production and lymphocyte proliferation which has a contrasting role by subsequently promoting the phosphorylation and inactivation of CARMA1. It governs antigen-receptor-induced NF-kappa-B activation and human lymphoma cell survival. These kinases are operationally defined by their preferential utilization of acidic proteins such as caseins as substrates. It can phosphorylate a large number of proteins including CTNNB1, PER1, and PER2. CSNK1A1 also participates in Wnt signaling. It may play a role in segregating chromosomes during mitosis, as well as, cytoskeleton diassembly which may regulate epithelial cell migration.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Protein Aliases: casein kinase 1, alpha 1-like; casein kinase I alpha S-like; Casein kinase I isoform alpha-like; CK1; CKI-alpha-like
Gene Aliases: CK1; CSNK1A1L
UniProt ID: (Human) Q8N752
Entrez Gene ID: (Human) 122011
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