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Invitrogen
Human PIK3C2G (PI3K-C2 gamma), GST Tag Recombinant Protein
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Product Details
A32907
Product Specifications
Species
Human
Expression System
Insect cells
Amino acid sequence
468-1203
Tag
GST-tag
Molecular weight
110 kDa
Class
Recombinant
Type
Protein
Conjugate
Form
Liquid
Concentration
See Label
Amount
100 µg
Purification
purified
Storage buffer
50mM tris HCl, pH 7.5, with 0.1mM PMSF, 0.25mM DTT, 25% glycerol, 0.1mM EDTA, 150mM NaCl, 10mM glutathione
Contains
no preservative
Storage conditions
-80°C, Avoid Freeze/Thaw Cycles
Shipping conditions
Dry ice
Product Specific Information
For maximum recovery please spin prior to use. Unless noted below, aliquots of the 5 µg, 10 µg and 20 µg sizes of kinase are not recommended as materials can be used in original packaging until exhausted. For larger sizes, the number of freeze/thaws may be reduced by preparing aliquots, aliquots below 20 µL are not recommended. Please never store a kinase diluted. If properly stored at -80C, this product is guaranteed for 6 months from date of purchase.
This PIK3C2G (PI3K-C2 gamma) recombinant human protein (468-1203) was expressed in insect cells.
PIK3C2G (PI3K-C2 gamma) recombinant human protein is also available in our SelectScreen™ Kinase Profiling Service.
• Validated for use with the Adapta™ assay
• Available in multiple pack sizes for convenient use
• Also available in our SelectScreen Kinase Profiling Service
Protein Form: Recombinant, Active, Catalytic
The gene accession number for PIK3C2G (PI3K-C2 gamma) is AAI30278.1.
Target Information
PIK3C2G lipid kinase belongs to the phosphoinositide 3-kinase (PI3K) family which play major roles in signaling pathways and are involved in cell proliferation, oncogenic transformation, cell survival, cell migration, and intracellular protein trafficking. PIK3C2G contains a lipid kinase catalytic domain as well as a C-terminal C2 domain, a characteristic of class II PI3-kinases that act as calcium-dependent phospholipid binding motifs which mediate translocation of proteins to membranes, and may also mediate protein-protein interactions. The N-terminal region of PIK3C2G and the C-terminal C2 domain are required for enzymatic activity. The PI 3-kinase C2gamma gene encodes a 1,050 amino acid polypeptide with 36% identity to human PI 3-kinase C2alpha. Research indicates that PI 3-kinase C2gamma can block the growth of human colon cancer cells.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: Phosphatidylinositol 3-kinase C2 domain-containing subunit gamma; phosphatidylinositol-4-phosphate 3-kinase C2 domain-containing gamma polypeptide; phosphatidylinositol-4-phosphate 3-kinase C2 domain-containing subunit gamma; Phosphoinositide 3-kinase-C2-gamma; phosphoinositide-3-kinase, class 2, gamma polypeptide; PI 3-kinase C2gamma; PI3K-C2-gamma; PI3KC2gamma; PTDINS-3-kinase C2 gamma
Gene Aliases: PI3K-C2-gamma; PI3K-C2GAMMA; PIK3C2G
UniProt ID: (Human) O75747
Entrez Gene ID: (Human) 5288
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