Invitrogen™

MAPK7 (ERK5) Recombinant Human Protein

Catalog number:  A33362

Related applications:

Pharma & Biopharma

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Description

This MAPK7 (ERK5) recombinant human protein (full length) was expressed in insect cells. MAPK7 (ERK5) serine/threonine kinase is a member of the MAP kinase family and is involved in a wide variety of cellular processes such as proliferation, differentiation, transcription regulation and development. MAPK7 is activated by mitogen-activated protein kinase kinase 5 (MAP2K5/MEK5) and is involved in downstream signaling processes of various receptors. In response to extracelluar signals, MAPK7 translocates to the cell nucleus where it regulates gene expression by phosphorylating and activating different transcription factors. Gene deletion of MAPK7 in mice results in defective blood vessel and cardiac development leading to embryonic lethality. MAPK7 has been shown to be critical for endothelial function and maintenance of blood vessel integrity. MAPK7 (ERK5) recombinant human protein is also available in our SelectScreen™ Kinase Profiling Service.

• Validated for use with the Z’-LYTE™ assay
• Available in multiple pack sizes for convenient use
• Also available in our SelectScreen Kinase Profiling Service

For Research Use Only. Not for use in diagnostic procedures.

Specifications

Accession Number: NP_620602
Shipping Condition: Dry Ice
Expression System: Insect
Protein Form: Full Length, Recombinant, Active
Species: Human
Validated Application: Kinase Assay
Molecular Weight: 114.7 kDa
KinaseFamily: MAP Kinases
Protein Length: Full Length
Protein Tag: GST Tag

Contents & storage

Storage Buffer: 50 mM Tris-HCl, pH 7.5, 150 mM NaCl, 10 mM glutathione, 0.1 mM EDTA, 0.25 mM DTT, 0.1 mM PMSF, 25% glycerol.