Invitrogen™

TEK (TIE2) Y897S Recombinant Human Protein

Catalog number: A33368
Invitrogen™

TEK (TIE2) Y897S Recombinant Human Protein

Catalog number: A33368
Catalog Number
A33368
Unit Size
1 mg
Price (USD)
6,570.00
Your Price:
Availability
***
Quantity
Catalog Number
Unit Size
10 µg
Price (USD)
449.00
Your Price:
Availability
***
Quantity
Catalog Number
Unit Size
100 µg
Price (USD)
2,115.00
Your Price:
Availability
***
Quantity
Catalog NumberUnit SizePrice (USD)AvailabilityQuantity
A333681 mg
6,570.00
Your Price:
***
A3051910 µg
449.00
Your Price:
***
A32878100 µg
2,115.00
Your Price:
***
Product Overview
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Additional Information
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This TEK (TIE2) Y897S recombinant human protein (771–end) was expressed in insect cells. TEK (TIE2) Y897S receptor tyrosine kinase is expressed principally on vascular endothelium. Disrupting TEK Y897S function in mice results in embryonic lethality with defects in embryonic vasculature, suggesting a role in blood vessel maturation and maintenance. Angiopoietin-1 is a secreted growth factor that binds to and activates the TEK receptor tyrosine kinase. SHP2 and GRB2 are recruited to the activated TEK kinase domain and are part of the cellular responses that mediate TEK function. TEK expression is upregulated in the endothelium of vascular 'hot spots' in human breast cancer specimens. However, TEK is also overexpressed in areas of active angiogenesis in normal tissues. TEK (TIE2) Y897S recombinant human protein is also available in our SelectScreen™ Kinase Profiling Service.

• Validated for use with the Z’-LYTE™ assay
• Available in multiple pack sizes for convenient use
• Also available in our SelectScreen Kinase Profiling Service

For Research Use Only. Not for use in diagnostic procedures.

Specifications

Accession Number
NP_000450
Shipping Condition
Dry Ice
Expression System
Insect
Form
Liquid
Protein Form
Recombinant, Active, Catalytic
Species
Human
Validated Application
Kinase Assay
Molecular Weight
66.7 kDa
Quantity
1 mg
KinaseFamily
TIE Kinase Family
Protein Length
aa 771 - end
Recombinant
Yes
Protein Tag
GST Tag

Contents & Storage

Storage Buffer: 50 mM Tris-HCl, pH 7.5, 150 mM NaCl, 10 mM glutathione, 0.1 mM EDTA, 0.25 mM DTT, 0.1 mM PMSF, 25% glycerol.

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Citations & References