This MAP2K4 (MEK4) recombinant human protein (full length) was expressed in insect cells. MAP2K4 (MEK4) serine/threonine kinase (mitogen-activated protein kinase kinase 4) MEK4 or MKK4 is a dual specificity kinase of the STE7 family that phosphorylates and activates JNK1 and -2 as well as p38. MAP2K4 preferentially phosphorylates the tyrosine residue of JNKs. MAP2K4 mediates a variety of physiological and pathophysiological processes such as responses to cellular stresses and inflammatory cytokines. MAP2K4 is important for carcinogenesis; a loss-off-function mutation in MAP2K4 was found in lung and pancreatic tumors. Conversely, a pro-oncogenic role was also found for MAP2K4. MAP2K4 (MEK4) recombinant human protein is also available in our SelectScreen™ Kinase Profiling Service.
• Validated for use with the LanthaScreen™ Eu Kinase Binding assay • Available in multiple pack sizes for convenient use • Also available in our SelectScreen Kinase Profiling Service
For Research Use Only. Not for use in diagnostic procedures.
Full Length, Recombinant, Active
Contents & Storage
Storage Buffer: 50 mM Tris-HCl, pH 7.5, 150 mM NaCl, 10 mM glutathione, 0.1 mM EDTA, 0.25 mM DTT, 0.1 mM PMSF, 25% glycerol.