Invitrogen™

MAP2K4 (MEK4) Recombinant Human Protein

Catalog number:  A33379

Related applications:

Pharma & Biopharma

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Description

This MAP2K4 (MEK4) recombinant human protein (full length) was expressed in insect cells. MAP2K4 (MEK4) serine/threonine kinase (mitogen-activated protein kinase kinase 4) MEK4 or MKK4 is a dual specificity kinase of the STE7 family that phosphorylates and activates JNK1 and -2 as well as p38. MAP2K4 preferentially phosphorylates the tyrosine residue of JNKs. MAP2K4 mediates a variety of physiological and pathophysiological processes such as responses to cellular stresses and inflammatory cytokines. MAP2K4 is important for carcinogenesis; a loss-off-function mutation in MAP2K4 was found in lung and pancreatic tumors. Conversely, a pro-oncogenic role was also found for MAP2K4. MAP2K4 (MEK4) recombinant human protein is also available in our SelectScreen™ Kinase Profiling Service.

• Validated for use with the LanthaScreen™ Eu Kinase Binding assay
• Available in multiple pack sizes for convenient use
• Also available in our SelectScreen Kinase Profiling Service

For Research Use Only. Not for use in diagnostic procedures.

Specifications

Accession Number: NP_003001
Shipping Condition: Dry Ice
Expression System: Insect
Protein Form: Full Length, Recombinant, Active
Species: Human
Validated Application: Kinase Assay
Molecular Weight: 70.6 kDa
KinaseFamily: MAP Kinases
Protein Length: Full Length
Protein Tag: GST Tag

Contents & storage

Storage Buffer: 50 mM Tris-HCl, pH 7.5, 150 mM NaCl, 10 mM glutathione, 0.1 mM EDTA, 0.25 mM DTT, 0.1 mM PMSF, 25% glycerol.