Invitrogen™

MAP2K5 (MEK5) Recombinant Human Protein

Catalog number:  A33380

Related applications:

Pharma & Biopharma

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Description

This MAP2K5 (MEK5) recombinant human protein (full length) was expressed in insect cells. MAP2K5 (MEK5) serine/threonine kinase (mitogen-activated protein kinase kinase 5) or MEK5 is a dual specificity protein kinase that belongs to the MAP kinase kinase family which specifically interacts with and activates MAPK7/ERK5. MAP2K5 itself can be phosphorylated and activated by MAP3K3/MEKK3, as well as by atypical protein kinase C isoforms (aPKCs). The signal cascade mediated by MAP2K5 is involved in growth factor stimulated cell proliferation and muscle cell differentiation. The rs3743354 polymorphism in the MAP2K5 promoter may affect the risk of developing colorectal cancer (CRC). MAP2K5 (MEK5) recombinant human protein is also available in our SelectScreen™ Kinase Profiling Service.

• Validated for use with the LanthaScreen™ Eu Kinase Binding assay
• Available in multiple pack sizes for convenient use
• Also available in our SelectScreen Kinase Profiling Service

For Research Use Only. Not for use in diagnostic procedures.

Specifications

Accession Number: AAH08838
Expression: Insect
Kinase Family: MAP Kinases
Molecular Weight: 76.4 kDa
Product Size: 1 mg
Protein Form: Active,Full Length,Recombinant
Protein Length or Portion (a.a.): Full Length
Protein Tag or Fusion: GST Tag
Shipping Condition: Dry Ice
Validated Application: Kinase Assay

Contents & storage

Storage Buffer: 50 mM Tris-HCl, pH 7.5, 150 mM NaCl, 10 mM glutathione, 0.1 mM EDTA, 0.25 mM DTT, 0.1 mM PMSF, 25% glycerol.