Invitrogen™

PI4K2A (PI4K2 alpha) Recombinant Human Protein

Catalog number:  A33390

Related applications:

Pharma & Biopharma

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Description

This PI4K2A (PI4K2 alpha) recombinant human protein (full length) was expressed in insect cells. PI4K2A (PI4K2 alpha) lipid kinase or phosphatidylinositol 4-kinase type 2 alpha is involved in the formation of phosphatidylinositolpolyphosphates (PtdInsPs) which are centrally involved in many biologic processes ranging from cell growth and organization of the actin cytoskeleton to endo- and exocytosis. PI4K2A phosphorylates PtdIns at the D-4 position which is an essential step in the biosynthesis of PtdInsPs. PI4K2A is a novel regulator of tumor growth by its action on angiogenesis and HIF-1alpha regulation. PI4K2A generates PtdIns4P-rich domains within the Golgi which regulate targeting of clathrin adaptor AP-1 complexes. PI4K2A is also required for Wnt to regulate LRP6 phosphorylation. PI4K2A (PI4K2 alpha) recombinant human protein is also available in our SelectScreen™ Kinase Profiling Service.

• Validated for use with the Adapta™ assay
• Available in multiple pack sizes for convenient use
• Also available in our SelectScreen Kinase Profiling Service

For Research Use Only. Not for use in diagnostic procedures.

Specifications

Accession Number: NP_060895
Shipping Condition: Dry Ice
Expression System: Insect
Protein Form: Full Length, Recombinant, Active
Validated Application: Kinase Assay
Molecular Weight: 80.3 kDa
KinaseFamily: PI3 Kinase
Protein Length: Full Length
Protein Tag: GST Tag

Contents & storage

Storage Buffer: 50 mM Tris-HCl, pH 7.5, 150 mM NaCl, 10 mM glutathione, 0.1 mM EDTA, 0.25 mM DTT, 0.1 mM PMSF, 25% glycerol.