Invitrogen™

PIK3CA/PIK3R3 (p110 alpha /p55 gamma) Recombinant Human Protein

Catalog number:  A33393

Related applications:

Pharma & Biopharma

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Description

This PIK3CA/PIK3R3 (p110 alpha /p55 gamma) recombinant human protein (full length) was expressed in insect cells. PIK3CA/PIK3R3 lipid kinase (p110 alpha /p55 gamma) or Phosphatidylinositol 3-kinase (PIK3) phosphorylates the inositol ring of phosphatidylinositol at the 3-prime position which serves as second messenger in growth signaling pathways. PIK3CA comprises a 110 kDa catalytic subunit and a regulatory subunit of either 85, 55, or 50 kDa. PIK3CA plays an important role in the metabolic actions of insulin, and a mutation in the PIK3CA has been associated with insulin resistance and plays an important role in glucose homeostasis in vivo. PIK3CA also plays an essential role in the development and induction of mast cells in normal and pathogenic immune responses. PIK3CA/PIK3R3 (p110 alpha /p55 gamma) recombinant human protein is also available in our SelectScreen™ Kinase Profiling Service.

• Validated for use with the Adapta™ assay
• Available in multiple pack sizes for convenient use
• Also available in our SelectScreen Kinase Profiling Service

For Research Use Only. Not for use in diagnostic procedures.

Specifications

Accession Number: PIK3CA: NP_006209.2, PIK3R3: AAH21622
Shipping Condition: Dry Ice
Expression System: Insect
Protein Form: Full Length, Recombinant, Active
Validated Application: Kinase Assay
Molecular Weight: 125.4/56.3 kDa
KinaseFamily: PI3 Kinase
Protein Length: Full Length
Protein Tag: His Tag

Contents & storage

Storage Buffer: 50 mM sodium phosphate, pH 7.0, 300 mM NaCl, 150 mM imidazole, 0.1 mM PMSF, 0.25 mM DTT, 25% glycerol.