Invitrogen™

EGFR (ErbB1) d747-749 A750P Recombinant Human Protein

Catalog number: A33512
Invitrogen™

EGFR (ErbB1) d747-749 A750P Recombinant Human Protein

Catalog number: A33512
Catalog Number
A33512
Unit Size
10 µg
Price (USD)
504.00
Your Price:
Availability
***
Quantity
Catalog Number
Unit Size
100 µg
Price (USD)
2,795.00
Your Price:
Availability
***
Quantity
Catalog Number
Unit Size
1 mg
Price (USD)
7,930.00
Your Price:
Availability
***
Quantity
Catalog NumberUnit SizePrice (USD)AvailabilityQuantity
A3351210 µg
504.00
Your Price:
***
A33571100 µg
2,795.00
Your Price:
***
A337341 mg
7,930.00
Your Price:
***
Product Overview
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Additional Information
Recommendations
This EGFR (ErbB1) d747-749 A750P recombinant human protein (672–end) was expressed in insect cells. EGFR receptor tyrosine kinase is a transmembrane glycoprotein. Binding of epidermal growth factor to EGFR induces receptor dimerization and tyrosine autophosphorylation and leads to cell proliferation, differentiation, motility, and cell survival. Activation of EGFR triggers mitogenic signaling in gastrointestinal mucosa, and its expression is upregulated in colon cancers and most neoplasms. Activation of EGFR triggers activation of the ERK-signaling pathway in normal gastric epithelial and colon cancer cell lines. Inactivation of EGFR with selective inhibitors significantly reduces ERK2 activation, c-fos mRNA expression and cell proliferation. EGFR (ErbB1) d747-749 A750P recombinant human protein is also available in our SelectScreen™ Kinase Profiling Service.

• Validated for use with the LanthaScreen™ Eu Kinase Binding assay
• Available in multiple pack sizes for convenient use
• Also available in our SelectScreen Kinase Profiling Service

For Research Use Only. Not for use in diagnostic procedures.

Specifications

Accession Number
NP_005219.2
Shipping Condition
Dry Ice
Expression System
Insect
Form
Liquid
Protein Form
Recombinant, Active, Cytoplasmic, Mutant
Species
Human
Validated Application
Kinase Assay
Molecular Weight
88.8 kDa
Quantity
10 µg
KinaseFamily
EGF Receptors (ErbBs)
Protein Length
aa 672 - end
Recombinant
Yes
Protein Tag
GST Tag, His Tag

Contents & Storage

Storage Buffer: 50 mM HEPES pH 7.5, 100 mM NaCl, 5 mM DTT, 15 mM reduced glutathione, 20% glycerol

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Citations & References