Invitrogen™

EGFR (ErbB1) d747-749 A750P Recombinant Human Protein

Catalog number:  A33571

 Related applications:

Pharma & Biopharma

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Description

This EGFR (ErbB1) d747-749 A750P recombinant human protein (672–end) was expressed in insect cells. EGFR receptor tyrosine kinase is a transmembrane glycoprotein. Binding of epidermal growth factor to EGFR induces receptor dimerization and tyrosine autophosphorylation and leads to cell proliferation, differentiation, motility, and cell survival. Activation of EGFR triggers mitogenic signaling in gastrointestinal mucosa, and its expression is upregulated in colon cancers and most neoplasms. Activation of EGFR triggers activation of the ERK-signaling pathway in normal gastric epithelial and colon cancer cell lines. Inactivation of EGFR with selective inhibitors significantly reduces ERK2 activation, c-fos mRNA expression and cell proliferation. EGFR (ErbB1) d747-749 A750P recombinant human protein is also available in our SelectScreen™ Kinase Profiling Service.

• Validated for use with the LanthaScreen™ Eu Kinase Binding assay
• Available in multiple pack sizes for convenient use
• Also available in our SelectScreen Kinase Profiling Service

For Research Use Only. Not for use in diagnostic procedures.

Specifications

Accession Number: NP_005219.2
Molecular Weight: 88.8 kDa
Product Size: 100 µg
Protein Length or Portion (a.a.): aa 672 - end
Protein Tag or Fusion: GST Tag, His Tag
Validated Application: Kinase Assay
Expression: Insect
Kinase Family: EGF Receptors (ErbBs)
Protein Form: Active, Cytoplasmic, Mutant, Recombinant
Shipping Condition: Dry Ice

Contents & storage

Storage Buffer: 50 mM HEPES pH 7.5, 100 mM NaCl, 5 mM DTT, 15 mM reduced glutathione, 20% glycerol

Documents

Manuals & protocols