Invitrogen™

ABL1 F317L Recombinant Human Protein

Catalog number:  A33719

Related applications:

Pharma & Biopharma

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Description

This ABL1 F317L recombinant human protein (27–end) was expressed in insect cells. ABL1 cytoplasmic tyrosine kinase protooncogene encodes a cytoplasmic and nuclear kinase that has been implicated in processes of cell differentiation, cell division, cell adhesion, and stress response. Activity of ABL protein is negatively regulated by its SH3 domain and deletion of the SH3 domain turns ABL1 into an oncogene. Translocation and head-to-tail fusion of the BCR and ABL1 genes is present in many cases of chronic myelogeneous leukemia. The DNA-binding activity of the ubiquitously expressed ABL1 tyrosine kinase is regulated by CDK1-mediated phosphorylation, suggesting a cell cycle function for ABL1. ABL1 F317L recombinant human protein is also available in our SelectScreen™ Kinase Profiling Service.

• Validated for use with the Z’-LYTE™ assay
• Available in multiple pack sizes for convenient use
• Also available in our SelectScreen Kinase Profiling Service

For Research Use Only. Not for use in diagnostic procedures.

Specifications

Accession Number: NP_005148.2
Shipping Condition: Dry Ice
Expression System: Insect
Protein Form: Recombinant, Active, Mutant
Validated Application: Kinase Assay
Molecular Weight: 146.3 kDa
KinaseFamily: ABL Kinase Family
Protein Length: aa 27 - end
Protein Tag: GST Tag

Contents & storage

Storage Buffer: 50 mM Tris-HCl, pH 7.5, 150 mM NaCl, 10 mM glutathione, 0.1 mM EDTA, 0.25 mM DTT, 0.1 mM PMSF, 25% glycerol.