Invitrogen™

CSNK1E (CK1 epsilon) R178C Recombinant Human Protein

Catalog number:  A33721

Related applications:

Pharma & Biopharma

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Description

This CSNK1E (CK1 epsilon) R178C recombinant human protein (full length) was expressed in insect cells. CSNK1E serine/threonine kinase is a member of the CK1 family which plays an important role in diverse cell processes, including DNA replication and repair. CSNK1E is a regulator of Yes-associated protein (YAP) transcription coactivator, which is a key regulator of organ size and a candidate human oncogene. CSNK1E is activated by CCK2R and then phosphorylates PKD2 at Ser244. Phosphorylation of PKD2 leads to its nuclear accumulation and efficient phosphorylation of nuclear PKD2 substrates in human gastric cancer cells. CSNK1E can phosphorylate topoisomerase (topo) II alpha at serine-1106 and this regulates the enzyme activity and sensitivity to topo II-targeted drugs. CSNK1E (CK1 epsilon) R178C recombinant human protein is also available in our SelectScreen™ Kinase Profiling Service.

• Validated for use with the Z’-LYTE™ assay
• Available in multiple pack sizes for convenient use
• Also available in our SelectScreen Kinase Profiling Service

For Research Use Only. Not for use in diagnostic procedures.

Specifications

Accession Number: NP_001885.1
Shipping Condition: Dry Ice
Expression System: Insect
Protein Form: Full Length, Recombinant, Active
Species: Human
Validated Application: Kinase Assay
Molecular Weight: 73.6 kDa
KinaseFamily: CK1 Kinase Family
Protein Length: Full Length
Protein Tag: GST Tag

Contents & storage

Storage Buffer: 50 mM Tris-HCl, pH 7.5, 150 mM NaCl, 10 mM glutathione, 0.1 mM EDTA, 0.25 mM DTT, 0.1 mM PMSF, 25% glycerol