Invitrogen™

RET V804E Recombinant Human Protein

Catalog number:  A33730

Related applications:

Pharma & Biopharma

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Description

This RET V804E recombinant human protein (858–1114) was expressed in insect cells. RET receptor tyrosine kinase or ret proto-oncogene is a member of the cadherin superfamily which are cell-surface receptors that transduce signals for cell growth and differentiation. RET can undergo oncogenic activation in vivo and in vitro by cytogenetic rearrangement. Mutations in the RET gene are associated with the disorders multiple endocrine neoplasia, type IIA, multiple endocrine neoplasia, type IIB, Hirschsprung disease, and medullary thyroid carcinoma. RET signaling pathway, by regulating the development of both the nervous and lymphoid system in the gut, plays a key role in the molecular mechanisms that orchestrate intestine organogenesis. RET V804E recombinant human protein is also available in our SelectScreen™ Kinase Profiling Service.

• Validated for use with the Z’-LYTE™ assay
• Available in multiple pack sizes for convenient use
• Also available in our SelectScreen Kinase Profiling Service

For Research Use Only. Not for use in diagnostic procedures.

Specifications

Accession Number: NP_065681.1
Shipping Condition: Dry Ice
Expression System: Insect
Protein Form: Recombinant, Active, Cytoplasmic, Mutant
Validated Application: Kinase Assay
Molecular Weight: 80.5 kDa
KinaseFamily: RET Kinase Family
Protein Length: aa 858 - 1114
Protein Tag: GST Tag

Contents & storage

Storage Buffer: 50 mM HEPES pH 7.5, 100 mM NaCl, 5 mM DTT, 15 mM reduced glutathione, 20% glycerol