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Alomone Labs, LTD
CLIC1 Polyclonal Antibody
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FIGURE: 1 / 2
CLIC1 Antibody (ACL-021-50UL) in ICC/IF
Expression of CLIC1 in human colorectal adenocarcinoma HT-29 cells - Immunocytochemical staining of fixed and permeabilized human colorectal adenocarcinoma HT-29 cells. A. Cells were stained with Anti-CLIC1 Antibody (#ACL-021), (1:200), followed by goat Anti-rabbit-AlexaFluor-594 secondary Antibody (red). B. Cell nuclei were visualized using Hoechst 33342 (blue). C. Merge of the two images.
Product Details
ACL-021-50UL
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
(C)RGFTIPEAFRGVHR, corresponding to amino acid residues 195-208 of human CLIC1, Intracellular, C-terminus
Conjugate
Form
Lyophilized
Concentration
0.8 mg/mL
Amount
40 µg
Purification
Antigen affinity chromatography
Storage buffer
PBS, pH 7.4, with 1% BSA
Contains
0.05% sodium azide
Storage conditions
-20°C, Avoid Freeze/Thaw Cycles
Shipping conditions
Ambient (domestic); Wet ice (international)
Product Specific Information
Reconstitution: 50 µL or 0.2 mL double distilled water (DDW), depending on the sample size. The antibody ships as a lyophilized powder at room temperature. Upon arrival, it should be stored at -20C. The reconstituted solution can be stored at 4C, protected from the light, for up to 1 week. For longer periods, small aliquots should be stored at -20C. Avoid multiple freezing and thawing. Centrifuge all antibody preparations before use (10000 X g 5 min).
Target Information
Chloride channels are a diverse group of proteins that regulate fundamental cellular processes including stabilization of cell membrane potential, transepithelial transport, maintenance of intracellular pH, and regulation of cell volume. Chloride intracellular channel 1 is a member of the p64 family; the protein localizes principally to the cell nucleus and exhibits both nuclear and plasma membrane chloride ion channel activity.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: 27kDa protein; Chloride channel ABP; Chloride intracellular channel protein 1; chloride intracellular channel protein 1 {ECO:0000250|UniProtKB:O00299, ECO:0000312|EMBL:CAE83985.1}; CLIC1; clic1 {ECO:0000312|EMBL:CAE83985.1, ECO:0000312|RGD:1303043}; DADB-110M10.1; FLJ94671; Glutaredoxin-like oxidoreductase CLIC1; Glutathione-dependent dehydroascorbate reductase CLIC1; hRNCC; NCC27; Nuclear chloride ion channel 27; nuclear chloride ion channel protein; p64 CLCP; p64CLCP; Regulatory nuclear chloride ion channel protein; RNCC protein; unnamed protein product
Gene Aliases: CL1C1; CLCNL1; Clcp; CLIC1; G6; NCC27
UniProt ID: (Human) O00299, (Mouse) Q9Z1Q5, (Rat) Q6MG61
Entrez Gene ID: (Human) 1192, (Mouse) 114584, (Rat) 406864
ion transport
chloride transport
signal transduction
ion transmembrane transport
positive regulation of osteoblast differentiation
regulation of mitochondrial membrane potential
platelet aggregation
chloride transmembrane transport
transport
regulation of ion transmembrane transport
regulation of cell cycle
regulation of anion transport
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Clicking the images or links will redirect you to a website hosted by BenchSci that provides third-party scientific content. Neither the content nor the BenchSci technology and processes for selection have been evaluated by us; we are providing them as-is and without warranty of any kind, including for use or application of the Thermo Fisher Scientific products presented.
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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