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OriGene
PLEK Monoclonal Antibody (OTI4F10), TrueMAB™
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FIGURE: 1 / 3
PLEK Antibody (CF500899) in WB
HEK293T cells were transfected with the pCMV6-ENTRY control (Left lane) or pCMV6-ENTRY PLEK (RC203780, Right lane) cDNA for 48 hrs and lysed. Equivalent amounts of cell lysates (5 µg per lane) were separated by SDS-PAGE and immunoblotted with anti-PLEK. Positive lysates LY419171 (100 µg) and LC419171 (20 µg) can be purchased separately from OriGene.
Product Details
CF500899
Product Specifications
Species Reactivity
Human
Host/Isotype
Mouse
/ IgG2a
Class
Monoclonal
Type
Antibody
Clone
OTI4F10
Immunogen
Full length human recombinant protein of human PLEK produced in HEK293T cell.
Conjugate
Form
Lyophilized
Concentration
1 mg/mL
Amount
100 µg
Purification
Affinity chromatography
Storage buffer
PBS, pH 7.3, with 8% trehalose
Contains
no preservative
Storage conditions
-20°C, Avoid Freeze/Thaw Cycles
Shipping conditions
Ambient (domestic); Wet ice (international)
Product Specific Information
For reconstitution, we recommend adding 100 µL distilled water to a final antibody concentration of about 1 mg/mL. To use this carrier-free antibody for conjugation experiments, we strongly recommend performing another round of desalting. (Zeba Spin Desalting Columns, 7KMWCO, 0.5 mL, Product # 89882)
Target Information
Major protein kinase C substrate of platelets.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: FLJ27168; p47; Platelet 47 kDa protein; Pleckstrin; PLEK; unnamed protein product
Gene Aliases: P47; PLEK; PLEK1
UniProt ID: (Human) P08567
Entrez Gene ID: (Human) 5341
hematopoietic progenitor cell differentiation
platelet degranulation
vesicle docking involved in exocytosis
phospholipase C-activating G-protein coupled receptor signaling pathway
integrin-mediated signaling pathway
positive regulation of platelet activation
negative regulation of inositol phosphate biosynthetic process
cell projection organization
actin cytoskeleton organization
positive regulation of actin filament depolymerization
phospholipase C-inhibiting G-protein coupled receptor signaling pathway
cortical actin cytoskeleton organization
ruffle organization
positive regulation of actin filament bundle assembly
positive regulation of integrin activation
intracellular signal transduction
inositol phosphate metabolic process
positive regulation of cellular component biogenesis
negative regulation of G-protein coupled receptor protein signaling pathway
negative regulation of calcium-mediated signaling
regulation of cell diameter
thrombin receptor signaling pathway
negative regulation of thrombin receptor signaling pathway
platelet aggregation
protein secretion by platelet
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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