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Invitrogen
HLA-DR Monoclonal Antibody (Tü36), Pacific Green™
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FIGURE: 1 / 1
HLA-DR Antibody (H11212) in Flow
Samples were acquired and analyzed using 405 nm excitation and 522/31 nm band pass emission filters on an Attune® Acoustic Focusing Cytometer. The histogram shows cells stained with HLADR (class II) Mouse Anti-Human Pacific Green™ Conjugate (black line), and unstained cells (gray line).
Product Details
H11212
Product Specifications
Host/Isotype
Mouse
/ IgG2b
Class
Monoclonal
Type
Antibody
Clone
Tü36
Immunogen
Human HLA-DR
Conjugate
Excitation/Emission Max
415/502 nm
View spectra
Form
Liquid
Storage conditions
4°C
Shipping conditions
Ambient
RRID
Target Information
HLA-DR, like other MHC class II molecules, is a transmembrane glycoprotein composed of a 36 kDa alpha chain (DRA) and 27 kDa beta chain (DRB). The alpha chain gene contains 5 exons. Exon 1 encodes the leader peptide, exons 2 and 3 encode the two extracellular domains, and exon 4 encodes the transmembrane domain and the cytoplasmic tail. DRA does not have polymorphisms in the peptide binding part and acts as the sole alpha chain for DRB1, DRB3, DRB4 and DRB5. Within the DR molecule the beta chain contains all the polymorphisms specifying the peptide binding specificities. Hundreds of DRB1 alleles have been described and typing for these polymorphisms is routinely done for bone marrow and kidney transplantation. HLA-DR is expressed primarily on antigen presenting cells such as B lymphocytes, monocytes, macrophages, thymic epithelial cells and activated T lymphocytes. Three loci, DR, DQ and DP, encode the major expressed products of the human class II region. The human MHC class II molecules bind intracellularly processed peptides, present them to T-helper cells, and have a critical role in the initiation of the immune response.
HLA and MHC antibodies play a significant role in Immunopeptidomics, facilitating the identification and characterization of neoantigens through high-performance liquid chromatography coupled to tandem Mass Spectrometry.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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