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Bethyl Laboratories

BRG1/SMARCA4 Polyclonal Antibody

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BRG1/SMARCA4 Polyclonal Antibody

Product Details

IHC-00466-T

Applications
Tested Dilution
Publications

Immunohistochemistry (IHC)

1:100-1:500
-

Immunohistochemistry (Paraffin) (IHC (P))

1:100-1:500
-
Product Specifications

Species Reactivity

Human, Mouse

Host/Isotype

Rabbit / IgG

Class

Polyclonal

Type

Antibody

Immunogen

Region between residue 75 and 125 of human BRM/SWI2-Related Gene 1 (SWI/SNF Related, Matrix Associated, Actin Dependent Regulator of Chromatin, Subfamily A, member 4).
3D Epitope / Immunogen

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

0.20 mg/mL

Amount

2 µg

Purification

Antigen affinity chromatography

Storage buffer

TBS, pH 7.0 to 8.0, with 0.1% BSA

Contains

0.09% sodium azide

Storage conditions

4°C

Shipping conditions

Ambient (domestic); Wet ice (international)

Product Specific Information

The recommended shelf life for this product is 1 year from date of receipt.

Based on 100% sequence identity, this antibody is predicted to react with Dog, Horse, Rabbit, Panda, Orangutan, Monkey, Gorilla, Chimpanzee, Gray short-tailed opossum and hirteen-lined ground squirrel

Target Information

Brg1 (Brahma-related gene 1) is an ATPase subunit of SWI2/SNF2-like chromatin-remodeling complexes that enable access of regulatory and effector proteins in transcription, DNA repair and DNA replication. Although Brg1-containing complexes are not essential for general cell survival, they participate in transcriptional regulation of several hundred genes including those involved in interferon and stress response, immune cells differentiation, neurogenesis, cell cycle etc. and is absolutely necessary for mouse embryogenesis. Brg1 is also involved in cell growth arrest, senescence and tumour supression.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

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Bioinformatics

Protein Aliases: ATP-dependent helicase SMARCA4; BAF190A; brahma protein-like 1; BRG1-associated factor 190A; BRM/SWI2-related gene 1; FLJ39786; global transcription activator homologous sequence; homeotic gene regulator; Mitotic growth and transcription activator; nuclear protein GRB1; Protein brahma homolog 1; Protein BRG-1; SMARCA4; SNF2-beta; SNF2-like 4; sucrose nonfermenting-like 4; SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 4; SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily A member 4; Transcription activator BRG1; unnamed protein product

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Gene Aliases: b2b508.1Clo; b2b692Clo; BAF190; BAF190A; BRG1; CSS4; HP1-BP72; hSNF2b; MRD16; OTSC12; RTPS2; SMARCA4; SNF2; SNF2-beta; SNF2B; SNF2beta; SNF2L4; SNF2LB; SW1/SNF; SWI2

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UniProt ID: (Human) P51532, (Mouse) Q3TKT4

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Entrez Gene ID: (Human) 6597, (Mouse) 20586

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Function(s)
RNA polymerase I CORE element sequence-specific DNA binding transcription cofactor binding p53 binding DNA binding chromatin binding transcription coactivator activity transcription corepressor activity RNA binding helicase activity protein binding ATP binding DNA-dependent ATPase activity hydrolase activity ATPase activity Tat protein binding nucleosomal DNA binding histone binding identical protein binding androgen receptor binding DNA polymerase binding ATP-dependent chromatin remodeler activity nucleosome array spacer activity nucleotide binding RNA polymerase II regulatory region sequence-specific DNA binding RNA polymerase II core promoter proximal region sequence-specific DNA binding RNA polymerase II distal enhancer sequence-specific DNA binding RNA polymerase II transcription coactivator activity transcription factor binding hydrolase activity, acting on acid anhydrides hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides protein complex binding protein N-terminus binding lysine-acetylated histone binding DNA helicase
Process(es)
negative regulation of transcription from RNA polymerase II promoter RNA polymerase I preinitiation complex assembly neural retina development chromatin organization nucleosome disassembly chromatin remodeling regulation of transcription, DNA-templated regulation of transcription from RNA polymerase II promoter nervous system development positive regulation of cell proliferation regulation of mitotic metaphase/anaphase transition positive regulation of Wnt signaling pathway negative regulation of cell growth heterochromatin assembly positive regulation by host of viral transcription positive regulation of T cell differentiation negative regulation of cell differentiation positive regulation of cell differentiation positive regulation of myoblast differentiation positive regulation of gene expression, epigenetic negative regulation of transcription, DNA-templated positive regulation of transcription, DNA-templated positive regulation of transcription from RNA polymerase II promoter negative regulation of androgen receptor signaling pathway regulation of G0 to G1 transition positive regulation of cold-induced thermogenesis positive regulation of signal transduction by p53 class mediator positive regulation of transcription of nuclear large rRNA transcript from RNA polymerase I promoter positive regulation of stem cell population maintenance positive regulation of glucose mediated signaling pathway positive regulation of pri-miRNA transcription from RNA polymerase II promoter regulation of G1/S transition of mitotic cell cycle positive regulation of double-strand break repair regulation of nucleotide-excision repair cell morphogenesis blood vessel development vasculogenesis in utero embryonic development blastocyst growth blastocyst hatching liver development outflow tract morphogenesis nucleosome assembly methylation-dependent chromatin silencing transcription, DNA-templated transcription from RNA polymerase II promoter glial cell fate determination heart development DNA methylation on cytosine within a CG sequence chromatin modification stem cell population maintenance neurogenesis extracellular matrix organization keratinocyte differentiation regulation of cell migration forebrain development hindbrain development embryonic hindlimb morphogenesis aortic smooth muscle cell differentiation ATP-dependent chromatin remodeling negative regulation of apoptotic process positive regulation of DNA binding histone H3 acetylation embryonic organ morphogenesis epidermis morphogenesis positive regulation of sequence-specific DNA binding transcription factor activity definitive erythrocyte differentiation heart trabecula formation pharyngeal arch artery morphogenesis lens fiber cell development
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