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Doxycycline hyclate
Doxycycline hyclate
Doxycycline hyclate
Thermo Scientific Chemicals

Doxycycline hyclate

Doxycyclinhyclat, Doryx, CAS-Nr. 24390-14-5, ist die Hyclat-Salzform des Breitband-Antibiotikums, das als Doxycyclin bekannt ist.
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Menge:
25 g
100 g
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Katalognummer J60579.14
auch als J60579-14 bezeichnet
Preis (EUR)
88,65
Exklusiv online
98,80
Ersparnis 10,15 (10%)
Each
Menge:
25 g
Großbestellung oder individuelle Größe anfordern
Preis (EUR)
88,65
Exklusiv online
98,80
Ersparnis 10,15 (10%)
Each
Chemikalien-Kennzeichnungen
CAS24390-14-5
IUPAC Namedihydrogen bis((2E,4S,4aR,5S,5aR,6R,12aS)-2-[amino(hydroxy)methylidene]-4-(dimethylamino)-5,10,11,12a-tetrahydroxy-6-methyl-1,2,3,4,4a,5,5a,6,12,12a-decahydrotetracene-1,3,12-trione) ethanol hydrate dichloride
Molecular FormulaC46H58Cl2N4O18
InChI KeyQDDHZFKCHWYXJF-PCLMCNLLSA-N
SMILES[H+].[H+].O.[Cl-].[Cl-].CCO.C[C@@H]1[C@H]2[C@H](O)[C@H]3[C@H](N(C)C)C(=O)C(=C(N)O)C(=O)[C@@]3(O)C(=O)C2=C(O)C2=C(O)C=CC=C12.C[C@@H]1[C@H]2[C@H](O)[C@H]3[C@H](N(C)C)C(=O)C(=C(N)O)C(=O)[C@@]3(O)C(=O)C2=C(O)C2=C(O)C=CC=C12
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SpecificationsSpecification SheetDatenblatt
FormPowder or crystals or crystalline powder
Assay from Suppliers CofAReport assay (%) or potency (µg/mg)
pH2.0-3.0
Appearance (Color)Yellow
This Thermo Scientific Chemicals brand product was originally part of the Alfa Aesar product portfolio. Some documentation and label information may refer to the legacy brand. The original Alfa Aesar product / item code or SKU reference has not changed as a part of the brand transition to Thermo Scientific Chemicals.

Suitable for battery materials development.

General description
• Doxycycline hyclate is a broad-spectrum bacteriostatic antibiotic of the tetracycline class
• Doxycycline inhibits bacterial growth by preventing polypeptide formation via inhibition of at least one ribosomal subunit
• Known to reversibly bind the 30S ribosomal subunit and inhibit formation of the aminoacyl-tRNA/mRNA-ribosome complex
• Inhibits matrix metalloproteinases in many microorganisms
Applications
• Effective against the bacteria that cause Lyme disease, chlamydia, rickettsia and mycoplasma; suitable for antibiotic resistance testing and study of cellular mechanisms
• Intended for laboratory use only

RUO – Research Use Only

General References:

  1. Adrian, J.; Fernández, F.; Sánchez-Baeza, F.; Marco, M. P. Preparation of antibodies and development of an enzyme-linked immunosorbent assay (ELISA) for the determination of doxycycline antibiotic in milk samples. J Agric Food Chem. 2012, 60(15), 3837-46.
  2. Aleksic, T.; Baumann, B., Wagner, M.; Adler, G.; Wirth, T.; Weber, C. K. Cellular immune reaction in the pancreas is induced by constitutively active IkappaB kinase-2. Gut. 2007, 56(2), 227-36.
  3. Moore, A. L.; desJardins-Park, H. E.; Duoto, B. A.; Mascharak, S.; Murphy, M. P.; Irizarry, D. M.; Foster, D. S.; Jones, R. E.; Barnes, L. A.; Marshall, C. D; Ransom, R. C.; Wernig, G.; Longaker, M. T. Doxycycline Reduces Scar Thickness and Improves Collagen Architecture. Ann Surg. 2020, 272(1),183-193.
  4. Doxycycline host-directed therapy in human pulmonary tuberculosis.
  5. Miow Q. H.; Vallejo A. F.; Wang Y; Hong J. M.; Bai C., Teo F. S.; Wang A. D.; Loh H. R.; Tan T. Z.; Ding Y., She H. W.; Gan S. H.; Paton N. I.; Lum J.; Tay A.; Chee C. B.; Tambyah P. A.; Polak M. E.; Wang Y. T.; Singhal A.; Elkington P. T.; Friedland J. S.; Ong C. W. J Clin Invest. 2021 Aug 2;131(15):e141895. doi: 10.1172/JCI141895.