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Nicergoline
Nicergoline
Nicergoline
Thermo Scientific Chemicals

Nicergoline

CAS: 27848-84-6 | C24H26BrN3O3 | 484.394 g/mol
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Menge:
100 mg
1 g
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Katalognummer J63295.03
auch als J63295-03 bezeichnet
Preis (EUR)
303,00
Each
Menge:
1 g
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Preis (EUR)
303,00
Each
Chemikalien-Kennzeichnungen
CAS27848-84-6
IUPAC Name(2S,4R,7R)-4-[(5-bromopyridine-3-carbonyloxy)methyl]-2-methoxy-6,11-dimethyl-6,11-diazatetracyclo[7.6.1.0²,⁷.0¹²,¹⁶]hexadeca-1(16),9,12,14-tetraen-6-ium
Molecular FormulaC24H27BrN3O3
InChI KeyYSEXMKHXIOCEJA-FVFQAYNVSA-O
SMILESCO[C@]12C[C@@H](COC(=O)C3=CN=CC(Br)=C3)C[NH+](C)[C@@H]1CC1=CN(C)C3=CC=CC2=C13
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SpecificationsSpecification SheetDatenblatt
Appearance (Color)White to yellow
Assay from Supplier's CofA≥97.0%
FormPowder or granular powder
Nicergoline is an ergot derivative and vasodilator which increases blood flow in the brain. Nicergoline inhibits the vasoconstrictor effect of catecholamines by inhibiting the postsynaptic α1-adrenoceptors on vascular smooth muscle.

This Thermo Scientific Chemicals brand product was originally part of the Alfa Aesar product portfolio. Some documentation and label information may refer to the legacy brand. The original Alfa Aesar product / item code or SKU reference has not changed as a part of the brand transition to Thermo Scientific Chemicals.

Solubility
Soluble in alcohol, chloroform, and acetone. Insoluble in water.

Notes
Protect from heat. Store away from oxidizing agents.
RUO – Research Use Only

General References:

  1. Arcamone, F.; Glasser, A.G.; Grafnetterov, J.; Minghetti, A.; Nicolella, V. TStudies on the metabolism of ergoline derivatives: Metabolism of nicergoline∗ in man and in animals.BBiochemical Pharmacology.1972, 21, (16), 2205-2213.
  2. Bengt Winblad.; Mario Fioravanti.; Tomas Dolezal.; Inara Logina.; Ivan Gospodinov Milanov.; Dinu Cristian Popescu.; Alina Solomon. Therapeutic Use of Nicergoline.Clinical Drug Investigation.2008, 28, (9), 533-552.